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Aldactazide (spironolactone/HCTZ)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Aldactazide (Spironolactone/Hydrochlorothiazide) is a combination medication used to treat high blood pressure, congestive heart failure, and cirrhosis of the liver.

The active ingredients in Aldactazide are both diuretics. Spironolactone inhibits the activity of aldosterone in your kidneys, while hydrochlorothiazide inhibits sodium and water reabsorption. Both drugs cause increased urine output.

You can buy Aldactazide online at Canada Drugs Direct in the brand or generic form.

  • Brand name Aldactazide
    • 25mg/25mg tablets
  • Generic Spironolactone/Hydrochlorothiazide
    • 25mg/25mg tablets
    • 50mg/50mg tablets

Store your Aldactazide at room temperature and keep it out of reach of children.


You can take Aldactazide without regard to meals.

Avoid eating potassium-rich foods while using Aldactazide.

Take your Aldactazide tablets with a full glass of water.

Take Aldactazide only as prescribed by your doctor.

The usual maintenance dose of Aldactazide is 50mg/50mg to 100mg/100mg per day.

  • Your doctor could adjust your dose up or down to help you get the best results.


The active ingredients in Aldactazide are spironolactone and hydrochlorothiazide.

For a complete list of inactive ingredients of Aldactazide, click here or check the product packaging.

Fact Table
Formula C24H32O4S, C7H8ClN3O4S2
License US: FDA
Routes of administration By mouth
Legal status Rx Only
Chemical Name Spironolactone/ Hydrochlorothiazide
Elimination half-life 1.4 hours, 5.6-14.8 hours
Dosage (Strength) 25mg, 50mg
Pregnancy Risk not ruled out
Brands Aldactazide
Protein binding <90%, 40-68%
PubChem CID 24847844
MedlinePlus a601111
ChEBI 9241, 5778
ATC code C03AA03
DrugBank DB00421, DB00999
KEGG D10270
Bioavailability -


Aldactazide could interact with the following medications:


Do not use Aldactazide if you have a known allergy to any of the ingredients or sulfonamide derivatives.

Do not take Aldactazide if you have any of the following conditions:

  • Anuria
  • Acute renal insufficiency
  • Significant kidney impairment
  • Hypercalcemia
  • Hyperkalemia
  • Addison’s disease
  • Acute severe liver failure

If you are pregnant, breastfeeding, or considering becoming pregnant, talk to your doctor about the risks of using Aldactazide.

Aldactazide can cause hyperkalemia. Avoid taking unprescribed potassium supplements while using Aldactazide.

Hydrochlorothiazide could activate or worsen your lupus erythematosus. Discuss your risk with your doctor.

Hydrochlorothiazide can cause acute transient myopia and acute angle-closure glaucoma.

Side Effects

  • Weakness
  • Low blood pressure
  • Pancreatitis
  • Jaundice
  • Diarrhea
  • Vomiting
  • Sialoadenitis
  • Cramping
  • Constipation
  • Gastric irritation
  • Nausea
  • Anorexia
  • Acute myopia
  • Acute angle-closure glaucoma
  • Aplastic anemia
  • Agranulocytosis
  • Leukopenia
  • Hemolytic anemia
  • Thrombocytopenia
  • Necrotizing angiitis
  • Respiratory distress
  • Photosensitivity
  • Fever
  • Urticaria
  • Rash
  • Purpura
  • Electrolyte imbalance
  • Hyperglycemia
  • Glycosuria
  • Hyperuricemia
  • Muscle spasm
  • Vertigo
  • Paresthesia
  • Dizziness
  • Headache
  • Restlessness
  • Renal failure
  • Interstitial nephritis
  • Renal dysfunction
  • Erythema multiforme
  • Transient blurred vision
  • Xanthopsia
  • Gastric bleeding
  • Ulceration
  • Gynecomastia
  • Sexual difficulties
  • Menstrual abnormalities
  • Breast pain
  • Carcinoma of the breast
  • Vasculitis
  • Leg cramps
  • Lethargy
  • Confusion
  • Ataxia
  • Liver toxicity
  • Stevens-Johnson Syndrome
  • Toxic epidermal necrolysis
  • Alopecia


Other Considerations

  • Compare our Aldactazide price with your local drug store before you buy Aldactazide.
  • Aldactazide is also sometimes called “Aldactazide 25 25”.


  1. DailyMed - ALDACTAZIDE- SPIRONOLACTONE and hydrochlorothiazide TABLET, film coated. (2020). Retrieved May 22, 2020.
  2. Aldactazide drug interactions. (n.d.). Retrieved May 22, 2020.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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