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Dovato (Dolutegravir/Lamivudine)

Prescription medicineOnly Available By Prescription
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Strength Pack Size Qty
Strength
50/300mg
Pack Size
Qty

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Dovato (dolutegravir/lamivudine) is a medication used to treat Human Immunodeficiency Virus (HIV). It is a combination of two drugs that work together to disrupt the virus’s ability to replicate. You can buy Dovato as a 50mg/300mg tablet. Store your Dovato tablets at room temperature. 

Directions

  • You can take Dovato with or without food.
  • Dovato can lose its effectiveness if taken with certain products. Take Dovato at least two hours before, or six hours after consuming products that contain any of the following:
    • Calcium
    • Magnesium
    • Iron
    • Aluminum
  • If you miss a dose, do one of the following:
    • Take it as soon as you remember.
    • If you realize you missed a dose and it is almost time for your next tablet, then skip the dose you missed and continue with your regular schedule.
  • Do not take two doses of Dovato to make up for a missed dose.
  • Usual Dovato dosage:
    • Take one tablet by mouth once daily.

Ingredients

  • The active ingredients of Dovato are dolutegravir and lamivudine. Refer to the package insert for a full list of ingredients.
Fact Table
Formula C20H18F2N3NaO5, C8H11N3O3S
License US FDA
Routes of administration By mouth
Legal status US: Rx Only
Chemical Name Dolutegravir/Lamivudine
Elimination half-life Dolutegravir: ~14 hr Lamivudine: 13-19 hr
Dosage (Strength) 50/300mg
Pregnancy Not classified yet
Brands Dovato
Protein binding Dolutegravir: ~99% Lamivudine: 36%
PubChem CID 54726191, 60825
MedlinePlus a619043
ChEBI 76010, 63577
ATC code J05AR25
DrugBank DB08930, DB00709
KEGG D11522
Bioavailability -

Cautions

  • Dovato has a black box warning that reads: PATIENTS CO-INFECTED WITH HEPATITIS B VIRUS (HBV) AND HUMAN IMMUNODEFICIENCY VIRUS (HIV-1): EMERGENCE OF LAMIVUDINE-RESISTANT HBV AND EXACERBATIONS OF HBV
  • Dovato can interact with other drugs. Discuss all your medications with your physician.
    • Dovato can have a potentially life-threatening interaction with dofetilide.
  • Avoid Dovato if you have a known allergy to dolutegravir or lamivudine.  
  • You may be at a higher risk of severe adverse effects if you have underlying liver disease.
  • Dovato could be harmful to a fetus during the first trimester. If you are pregnant or considering becoming pregnant, discuss the risks with your physician.
  • Dovato can cause Immune Reconstitution Syndrome. Discuss your risk with your doctor before starting Dovato.

Side Effects

Dovato side effects include:

  • Severe Effects:
    • Lactic acidosis
    • Hepatitis Exacerbation
    • Hepatotoxicity
    • Injury of the liver
    • Immune Reconstitution Syndrome
    • Hypersensitivity Reaction
  • Common:
    • Nausea
    • Diarrhea
    • Headache
    • Insomnia
    • Fatigue

Other Considerations

  • Compare the Dovato price at Canada Drugs Direct to your local drug store.

References:

  1. Immune reconstitution inflammatory syndrome. (2019). Retrieved March 22, 2020, from https://www.uptodate.com/contents/immune-reconstitution-inflammatory-syndrome
  2. Dovato. (n.d.). Retrieved March 21, 2020, from https://www.micromedexsolutions.com/micromedex2
  3. DailyMed - DOVATO- DOLUTEGRAVIR sodium and lamivudine TABLET, film coated. (2019). Retrieved March 21, 2020, from https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=68e45422-43ed-4cfb-9356-fae88d14a53a


IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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