Epclusa (Sofosbuvir/Velpatasvir)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Epclusa (velpatasvir/sofosbuvir) is a combination product of two medications used to treat Hepatitis C. It works by disrupting the replication process of the virus that causes the disease. You can buy Epclusa online as a 400mg/100mg tablet. Store your Epclusa tablets at room temperature and keep them out of reach of children. 


  • You can take Epclusa without regard to meals.
  • Swallow Epclusa tablets whole. Do not crush or break them.
  • If you miss a dose:
    • Take the dose as soon as you remember, or
    • If it is almost time to take your next dose, then continue with your regular schedule.
    • Do not take an extra dose to make up for a missed dose.
  • Usual Dosage:
    • Take one tablet by mouth once daily for twelve weeks.
  • Finish your entire Epclusa prescription as directed by your physician.


  • The active ingredients in Epclusa are velpatasvir and sofosbuvir. Refer to the package insert for a full list of inactive ingredients.
Fact Table
Formula C22H29FN3O9P, C49H54N8O8
License US FDA
Routes of administration By mouth
Legal status US: Rx Only
Chemical Name Sofosbuvir/Velpatasvir
Elimination half-life -
Dosage (Strength) 200mg/50mg, 400mg/100mg
Pregnancy Not classified yet
Brands Epclusa
Protein binding 61-65%, >99.5%
PubChem CID 91885554
MedlinePlus a616034
ChEBI 85083, 133009
ATC code J05AP55
DrugBank DB08934, DB11613
KEGG D10827
Bioavailability -


  • Do not use Epclusa if you are allergic to any of the ingredients.
  • Epclusa can interact with other medications. Discuss all your medications with your physician.
  • Do not take antacids containing magnesium or aluminum within four hours of Epclusa.
  • If you are pregnant or intending to become pregnant, discuss the risks with your physician.
  • If you have ever had Hepatitis B, discuss the risks of taking Epclusa with your physician.

Side Effects

  • Common Side Effects:
    • Nausea
    • Headache
    • Fatigue
  • Serious Side Effects:
    • Bradyarrhythmia
    • Liver failure
    • Reactivation of Hepatitis B

Other Considerations

If the cost of Epclusa is too high, you can also buy Epclusa generic.


  1. DailyMed - EPCLUSA- VELPATASVIR and SOFOSBUVIR TABLET, film coated. (2019). Retrieved March 21, 2020
  2. Epclusa. (n.d.). Retrieved March 21, 2020,

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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