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Synvisc - One (Hylan)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Synvisc One (hylan) is an injectable medication used to treat pain caused by osteoarthritis of the knee. It is made from a substance normally found in your joints called hyaluronan. Synvisc One is usually used in patients who have already tried simple pain-reducing drugs but did not achieve adequate results. It works by lubricating the knee joint and acting as a shock absorber to reduce the pain associated with osteoarthritis. A single treatment of Synvisc One can provide relief of symptoms for up to six months. You can buy Synvisc One as a 48mg/6mL syringe that should be stored at room temperature.


  • Your physician will inject Synvisc One into your knee joint at their office. They may use a numbing agent to numb the skin at the injection site. They may also inject a numbing agent into your knee joint prior to injecting Synvisc One.
  • Click here to watch a video describing a Synvisc knee injection.
  • The usual dosage for Synvisc One is a single injection of 6mL.


  • The active ingredient in Synvisc One is hylan G-F 20.
Fact Table
Formula C14H21NO11
License US FDA
Routes of administration Injection
Legal status US: Rx Only
Chemical Name hylan G-F 20
Elimination half-life -
Dosage (Strength) 48mg/6ml
Pregnancy Not classified
Brands Synvisc - One
Protein binding -
PubChem CID 20030435
MedlinePlus -
ChEBI 16336
ATC code M09AX01
DrugBank DB08818
Bioavailability -


  • Do not use Synvisc if you are allergic to hyaluronan.
  • Avoid using Synvisc if you have a skin infection near the injection site.
  • Synvisc is not indicated for use anywhere but the knee.
  • If you are allergic to bird products, feathers, or eggs, discuss the risks of Synvisc with your physician.
  • Do not use Synvisc One if the packaging is opened or damaged.
  • If you are pregnant or considering becoming pregnant, discuss the risks of Synvisc with your physician.
  • Synvisc is not indicated for patients under the age of 21.

Side Effects

  • Mild to moderate pain at the injection site.
  • Swelling of the injection site.
  • Joint pain
  • Joint stiffness
  • Joint effusion
  • Joint warmth
  • Joint swelling
  • Walking disturbance

Other Considerations

  • Click here to learn more about arthritis.


  1. Osteoarthritis knee pain RELIEF: Synvisc-one® (Hylan G-f 20): For HCPs. (2019). Retrieved March 22, 2020
  2. Hylan Polymers A and B. (n.d.). Retrieved March 22, 2020

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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