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Premarin Cream (Conjugated Estrogens)

Prescription medicineOnly Available By Prescription

Top brand choice

Strength Pack Size Qty
0.625mg/g x 14 grams
Pack Size
0.625mg/g x 30 grams
Pack Size

You'll have option to make 4 interest-free payments by credit card once your order is confirmed using

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Premarin is a prescription medicated cream made to treat menopause, specifically for treating vaginal symptoms of menopause that may interfere with a woman's love life as well as personal comfort. It is formulated with a mixture of estrogen hormones and is effective for reducing dryness, burning, and irritation in the vaginal region directly caused by menopause. These symptoms are intolerable for many women at this stage of their life, so it's very fortunate that a medication like Premarin vaginal cream is available to help them reduce pain that occurs during sex as a direct result of menopause.

You can buy Premarin cream with a prescription at most pharmacies, and always pay the lowest price for this product when you order medication online from Canada Drugs Direct.


  • Wash hands before using. Remove cap from tube. Screw on nozzle end of applicator tube.
  • Gently squeeze the end of the tube to dispense the application dose. Use the stopping point indicators shown on the applicator tube to measure the correct amount.
  • Unscrew applicator from tube. Lie on back with knees up and insert applicator far into vaginal cavity and then press plunger down to dispense medication.

After application you should wash applicator with soap and water. Do not boil applicator or use hot water to clean it.


The active ingredient in Premarin vaginal cream is conjugated estrogens.


Inform your doctor of any history vaginal bleeding, cancer, blood clots, stroke, heart disease, liver disease, kidney disease, family medical history of angioedema, blood clotting disorders, high blood pressure, diabetes, high cholesterol or triglyceride levels, obesity, lupus, underactive thyroid (hypothyroidism), mineral imbalance in the blood, hypoparathyroidism, uterus problems like fibroids or endometriosis, gallbladder disease, asthma, seizures, migraine headaches, or porphyria blood disorder.

Any of these conditions may lead them to determine that use of Premarin is not suitable for you.

Do not smoke or use tobacco when using Premarin as doing so increases your risk of stroke, blood clots, high blood pressure, and heart attack for women who are older than the age of thirty-five (35).

Use of Premarin may not be suitable if you just had or will undergo surgery or if you will be confined to a chair or bed for a long time. This may increase your risk of getting blood clots.

Limit time in sun while using this vaginal menopause cream, as sunlight exposure may cause blotchy, dark areas on your face and skin (melasma). Avoid tanning booths and sun lamps too.


There is the possibility of drug interaction risks between Premarin cream with gabapentin / levothyroxine / lisinopril / omeprazole / Synthroid (levothyroxine) / tramadol / trazodone / Vitamin B12 (cyanocobalamin) / Vitamin C (ascorbic acid) / and Vitamin D3 (cholecalciferol).

You should tell your doctor about all Rx medications and other health supplements you are taking before receiving a prescription and proceeding to buy Premarin cream.

Side Effects

It is not common to experience Premarin cream side effects, but some individuals may experience breast pain, changes in vaginal discharge, cough or hoarseness, fever or chills, clear or white vaginal discharge, genital itching, lower back or side pain, continued pain during sexual intercourse, pelvis pressure or pain, along with pain or difficulty when urinating.

If these Premarin cream side effects are experienced, discontinue use and meet with your doctor again to discuss other ways to prevent pain with sex during menopause and treat vaginal menopause symptoms.

Premarin Cream (Conjugated Estrogens) Frequently Asked Questions

Click the links below to jump to the section of the FAQ you want to learn more about.

  1. How does Premarin Cream Work?
  2. Can Personal Lubricants Be Used in Place of Premarin Cream?
  3. How Often Should I Apply Premarin Cream?
  4. How Long Will Tube of Premarin Conjugated Estrogens Cream Last?
  5. How Long Until I Experience Results from Using Premarin Cream?
  6. Is Premarin Cream Available in a Generic?
  7. Is Premarin Cream Suitable for All Women?
  8. What are Common Premarin Cream Side Effects?
  1. How does Premarin Cream Work?

Hormonal levels for certain hormones drop as a woman becomes menopausal. Vaginal atrophy and dyspareunia occur because the lack of sufficient levels for one those hormones - estrogen - promotes less natural lubrication of the vaginal walls as the body no longer foresees the possibility of a pregnancy. Vaginal walls become thinner over time too. Premarin provides a mixture of estrogen hormones to replenish those levels and promote better lubrication so that a woman is able to enjoy intimacy with her partner.

  1. Can Personal Lubricants Be Used in Place of Premarin Cream?

The can be used for temporary relief from painful sex during menopause, but using a prescription menopause treatment medication like Premarin is a better choice for women who find sex painful during menopause. Providing conjugated estrogens provides more long-term dyspareunia relief and treatment for vaginal dryness, something which can continue for women after they've finished menopause. Women may also find that their symptoms are more severe periodically.

  1. How Often Should I Apply Premarin Cream?

The dosage frequency for Premarin Cream will be indicated in your prescription and based on your doctor's recommendation depending on the severity of these menopause symptoms. Treatment objectives will also determine how often to apply Premarin:

For dyspareunia or painful sex treatment:

Apply 2x per week or in a cyclic regimen of 21 days of therapy with 0.5mg dose followed by 7 days off therapy and not applying the cream until the next week begins to start the 28-day cycle again. This will be explained in your prescription

For vaginal atrophy treatment (VVA):

Apply in a cyclic regimen of 21 days of therapy (starting at 0.5mg dose with dosage adjustments made on level of effectiveness and response according to doctor and prescription) followed by 7 days off therapy and not applying the cream until the next week begins to start the 28-day cycle again. This will be explained in your prescription.

  1. How Long Will Tube of Premarin Conjugated Estrogens Cream Last?

As with all medicated creams, dosage strength and frequency of application will determine how long one tube of the medication will last for the user. Using standard Premarin cream dosage and treatment regimen most women will find one tube of Premarin Cream lasts them around 6 months. You can discuss this with your dispensing pharmacist if you would like to know more.

  1. How Long Until I Experience Results from Using Premarin Cream?

Most women will begin to see results from using Premarin Cream and less vaginal dryness or pain during sex at around the 12 week (3 month) point from beginning treatment. It is important to take your medication exactly as directed and consistently in order to have these expectations.

  1. Is Premarin Cream Available in a Generic?

Premarin Cream is not available in a generic equivalent at this time, but a generic conjugated estrogens cream may be available in the future. You can order Premarin Cream online from Canada Drugs Direct and pay less for branded Premarin and likely pay significantly less than you would at your local pharmacy.

  1. Is Premarin Cream Suitable for All Women?

No, it is not. Women who have a history of unusual vaginal bleeding, cancer, heart attack or stroke, or blood clots will not be suitable for using Premarin cream. Women who have or at risk of gallbladder disease or who are taking thyroid medication may also not be suitable for this medication. All of this will be determined based on your doctor's professional opinion.

  1. What are Common Premarin Cream Side Effects?

Common Premarin Cream side effects include headache, pelvic or breast pain, vaginitis or vaginal bleeding. Most women only have mild side effects if any when using Premarin for menopause symptoms relief.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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