Plaquenil (Hydroxychloroquine)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Plaquenil (hydroxychloroquine) is a medication that can be used to treat multiple diseases, including malaria, Lupus Erythematosus, and Rheumatoid Arthritis. The exact way Plaquenil works is not well known. It is believed to disrupt the cell functions of the organisms that cause malaria. For immune diseases like Lupus and Rheumatoid Arthritis, it acts by decreasing the body’s immune response.

Plaquenil comes as a 200mg tablet. Store Plaquenil at room temperature.


Take Plaquenil with a meal or a full glass of milk. The dose of Plaquenil depends on what it is used for:

  • Malaria: 800mg as a first dose. Then 400mg at 6hrs, 24hrs, and 48hrs after the first dose. Your doctor might use your weight to determine your weight to determine your dose. 
  • Prevention of Malaria: Take 400mg once a week for two weeks before traveling to an area with malaria. Continue taking 400mg once per week while in the area with malaria, and for four weeks after leaving the area. Take the dose on the same day each week. Your doctor might use your weight to determine your dose. 
  • Lupus: Take 200mg-400mg per day. You can take it as a single dose or divided into two dose. 
  • Rheumatoid Arthritis: Initially, take 400mg-600mg per day until you get a good response. You can take it as a single dose or divided into two doses. Once a good response occurs, your doctor might reduce your dose to 200mg-400mg per day 


The active ingredient of Plaquenil is hydroxychloroquine. A complete list of the inactive ingredients can be found in the package insert.


  • Plaquenil can cause permanent damage to your retina. Your doctor should check your eyes before starting your treatment. The risk of damage is higher for patients who take a high daily dose, who have kidney problems, and who use Plaquenil for more than five years.
  • Plaquenil can cause certain heart problems that can be fatal. You should discuss your risks for developing heart problems with your doctor before starting treatment. Your doctor may want to monitor your heart during your treatment.
  • Patients with psoriasis or porphyria might experience a worsening of symptoms. Discuss the risks and benefits of Plaquenil with your doctor.
  • In some rare cases, patients using Plaquenil have expressed suicidal thoughts.
  • Plaquenil can cause a severe drop in blood sugar. This drop could lead to loss of consciousness or death.
  • Plaquenil should be used with caution if you have liver disease. If you are an alcoholic or have a liver condition, you should discuss the risks of Plaquenil with your with your doctor.
  • If you have kidney problems, you should discuss the risks of using Plaquenil with your doctor. They may decide to decrease your dose or avoid using Plaquenil altogether.
  • Plaquenil is known to interact with several medications. Discuss all the medicines you use with your doctor.
  • Contact your doctor immediately if you see signs of rash or vision problems. These symptoms can mean your dose is too high.
  • You should discuss the risks of becoming pregnant while using Plaquenil with your doctor.
  • Plaquenil can pass into the breastmilk of nursing mothers. You should discuss the risks of breastfeeding with your doctor.

Side Effects

Plaquenil is known to cause several side effects, including:

  • Blood disorders
  • Heart disorders
  • Vertigo
  • Tinnitus
  • Nystagmus
  • Deafness
  • Permanent eye damage
  • Nausea
  • Vomiting
  • Diarrhea
  • Abdominal pain
  • Fatigue
  • Liver function abnormalities
  • Liver failure
  • Decreased appetite
  • Decreased blood sugar
  • Porphyria
  • Weight loss
  • Muscle pain
  • Headache
  • Dizziness
  • Seizure
  • Ataxia
  • Psychiatric problems
  • Itching and rash
  • Pigment changes of the skin, hair, and mucous membranes
  • Steven-Johnson syndrome

Other Considerations

You can buy Plaquenil online as a brand name product or as a Plaquenil generic product. Click here to learn how to place an order.


IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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