Oriahnn (Elagolix,Estradiol,Norethindrone acetate and Elagolix)

Prescription medicineOnly Available By Prescription

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We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

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  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
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  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
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What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Oriahnn (elagolix, estradiol, and norethindrone acetate) is a combination medication used to manage heavy menstrual bleeding caused by fibroids in premenopausal women. 

Fact Table


C32H29F5N3O5Na. C32H30F5N3O5. C18H24O2.C22H28O3


US DailyMed



Legal status


Chemical Name

Elagolix/estradiol/norethindrone acetate

Elimination half-life

5.9 and 14.5 hours

Dosage (Strength)



Consult Doctor



Protein binding


PubChem CID






ATC code






Routes of administration

By mouth


Oriahnn comes in capsules: 

One capsule for morning administration contains 300 mg of elagolix, 1 mg of estradiol, and 0.5 mg of norethindrone acetate.

One capsule for evening administration contains 300 mg of elagolix.

Oriahnn Dosage: 

Take one capsule (elagolix 300 mg, estradiol 1 mg, norethindrone acetate 0.5 mg) by mouth every morning and one capsule (elagolix 300 mg) by mouth every evening for up to 2 years.


Elagolix, a gonadotropin-releasing hormone (GnRH) receptor antagonist, estradiol, an estrogen, and norethindrone acetate, a progestin, are the active ingredients contained in Oriahnn.



See full prescribing information for complete boxed warning.

  • Estrogen and progestin combinations, including ORIAHNN, increase the risk of thrombotic or thromboembolic disorders, especially in women at increased risk for these events. 
  • ORIAHNN is contraindicated in women with current or a history of thrombotic or thromboembolic disorders and in women at increased risk for these events including women over 35 years of age who smoke or women with uncontrolled hypertension. 

Avoid taking Oriahnn if you:

  • Are a smoker and are older than 35 years old 
  • Have or had blood clots in your legs, lungs, or eyes
  • Have a vascular disease such as cerebrovascular disease, coronary artery disease, or peripheral vascular disease
  • Have heart valve or heart rhythm problems
  • Have a condition that makes your blood clot more than normal
  • Have high blood pressure that is uncontrolled by medication
  • Have diabetes with injury to the kidneys, eyes, nerves, or blood vessels
  • Have headaches accompanied by numbness, weakness, or vision changes or if you are older than 35 and have migraines with aura

Avoid taking Oriahnn if you are pregnant.

Avoid taking Oriahnn if you have osteoporosis.

Avoid taking Oriahnn if you currently have or had breast cancer or any other hormonally-sensitive cancer.

Avoid taking Oriahnn if you have liver problems or liver disease.

Avoid taking Oriahnn if you have undiagnosed irregular vaginal bleeding.

Avoid taking Oriahnn if you are allergic to any of its ingredients or excipients.


  • Before you start taking Oriahnn, inform your doctor:
    • Of all the medications you take, including prescription, over-the-counter, vitamins, and herbal supplements.
    • Of your allergies.
    • Of your health problems.
    • Of your pregnancy status.
    • Of your breastfeeding status.
  • Avoid consuming grapefruit or grapefruit juice while taking Oriahnn.
  • Your risk for heart attack, stroke, or blood clots is increased with the use of Oriahnn. Get emergency care right away if you have pain or swelling in your leg, breathing problems, vision problems, a sudden and severe headache, arm or leg weakness or numbness, trouble speaking, or chest, arm, or jaw pain or pressure.
  • Bone mineral density loss can occur with the use of Oriahnn.
  • Suicidal ideation can occur with the use Oriahnn. Get emergency care right away if you experience suidcidal ideation, suicidal thoughts, suicidal behavior, or anxiety, depression, or mood changes that are new or becoming worse.
  • Liver damage can occur with the use of Oriahnn. Get medical care immediately if you have yellowing of your skin or whites of your eyes, dark urine, tiredness, nausea, vomiting, swelling, stomach pain, or bruising.
  • High blood pressure can occur with the use of Oriahnn. Be sure to monitor your blood pressure during treatment with Oriahnn.
  • Changes in periods and the ability to recognize pregnancy can occur with the use of Oriahnn. Be sure to take a pregnancy test if you suspect that you are pregnant. If you are pregnant, Oriahnn should be discontinued. It is not known how hormonal birth control affects the way Oriahnn works. Women should use hormone-free birth control methods during treatment with Oriahnn and for 28 after stopping Oriahnn.
  • Increased blood sugar levels, cholesterol, and triglycerides can occur with the use of Oriahnn. 
  • The thinning or loss of hair can occur with the use of Oriahnn.
  • Laboratory tests, including tests for thyroid, cholesterol, and blood clotting, can be affected by Oriahnn.
  • Oriahnn contains FD and C Yellow No. 5 (tartrazine). This can cause an allergic reaction in patients who are sensitive.

Side Effects

Oriahnn can cause side effects that include, but are not limited to, headache, hot flashes, tiredness, and irregular vaginal bleeding. Contact your doctor immediately if you have side effects that bother you or won't go away.


  1. Oriahnn (elagolix, estradiol, and norethindrone acetate capsules; elagolix capsules), co-packaged for oral use. North Chicago, IL: AbbVie Inc.; 2021.
  2. Oriahnn. Important Safety Information. Accessed March 21, 2022.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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