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Narcan (Naloxone)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Narcan (naloxone) is a medication used as an antidote for opioids like oxycodone, hydrocodone, and heroin.  It works by competitively blocking opioids at their receptor sites to reduce the clinical effects. You can buy Narcan online as a nasal spray or injection. Store your Narcan at room temperature, and keep it away from children.


  • Ask your doctor about when it is appropriate to use Narcan.
  • How to use a Narcan Nasal Spray
    • Each nasal spray device contains a single dose. Do not re-use the device.
    • If an emergency overdose situation arises, follow these steps:
      • Check if the patient is overdosing by asking them. If they do not respond, check for the following symptoms:
        • Slow breathing
        • Small pupils
        • Inability to wake up
      • Lay the patient on their back to prepare for giving them a dose.
      • Remove a spraying device from the wrapper.
      • Gently insert the tip of the nozzle into the patient’s nostril and tilt their head back by lifting their neck.
      • Press the plunger of the spraying device to give the dose.
      • Call for emergency help.
    • How to use a Narcan Injection
      • Follow the instructions given by your doctor to administer intravenous injections.
      • If using an auto-injector device:
        • Remove the red safety guard.
        • Place the black end of the device against the outer thigh of the patient. Press firmly for five seconds to administer the dose.
        • Call for emergency help.
      • Usual dosage
        • For opiate overdose
          • Injectable solution – Give 0.4mg-2mg intravenously. You may have to repeat the dose every two to three minutes. If you have not achieved an adequate response after administering 10mg, reconsider the diagnosis of overdose. Narcan can also be given in the muscle (IM) or into the skin (SQ).
          • Nasal sprays – Give one spray (either 2mg or 4mg) into one nostril. You may have to repeat the dose every two to three minutes. Use alternating nostrils for each dose.


The active ingredient in Narcan is naloxone hydrochloride. See the package inserts for a full list of inactive ingredients.

Fact Table
Formula C19H21NO4
License US: FDA
Routes of administration Endotracheal, Intranasal
Legal status Rx Only
Chemical Name Naloxone
Elimination half-life 1 – 1.5 hours
Dosage (Strength) 400mg
Pregnancy -
Brands Narcan, Evzio, Nyxoid
Protein binding -
PubChem CID 5284596
MedlinePlus a612022
ChEBI 7459
ATC code A06AH04, V03AB15
DrugBank DB01183
KEGG D08249
Bioavailability 2% (by mouth) 50% (intranasally)


  • Do not use Narcan if the patient has a known allergy to any of the ingredients.
  • A patient could require multiple doses of Narcan, depending on the extent of their symptoms. Ask your doctor to help you monitor the patient during an opioid overdose.
  • After receiving a dose of Narcan, the patient could respond with agitation.
  • Do not use Narcan on newborn babies who were born to an opioid-addicted mother. They are at risk of severe withdrawals that could be life-threatening. Call for emergency help and follow the instructions provided.
  • Narcan can lead to opioid withdrawal symptoms in opioid-dependent patients.

Side Effects

  • Redness at the injection site
  • Dizziness
  • Headache
  • Cardiac arrest
  • High blood pressure
  • Low blood pressure
  • Increased heart rate
  • Ventricular fibrillation
  • Ventricular tachycardia
  • Sweating
  • Nausea
  • Vomiting
  • Coma
  • Encephalopathy
  • Seizure
  • Tremor
  • Pulmonary edema
  • Opioid withdrawal

Other Considerations

  • Where to get Narcan.
    • You can buy Narcan online or at your local drug store. Buy Narcan online from Canada Drugs Direct.
  • How does Narcan work?
    • Click here to see a video about how Narcan works.


  1. DailyMed - Naloxone HYDROCHLORIDE AUTO-INJECTOR- Naloxone Hydrochloride injection, solution. (2019). 
  2. DailyMed - NARCAN- Naloxone hydrochloride Spray NARCAN- Naloxone hydrochloride spray. (2019). 
  3. DailyMed - NALOXONE HYDROCHLORIDE- nalxone hydrochloride injection. (2018)
  4. Naloxone Hydrochloride. (n.d.). Retrieved April 01, 2020
  5. How Does Narcan Work? (2018). Retrieved April 10, 2020

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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