Motegrity (Prucalopride)

Also Known as Resotran

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Motegrity is a prescription prokinetic medication for treatment of chronic idiopathic constipation (CIC). It works by increasing the movement of the colon muscle (peristalsis) to promote easier bowel movement more effectively. The active ingredient Prucalopride targets a specific receptor in the colon and the body's natural peristalsis process for waste elimination from the colon is enhanced. You can buy Motegrity medication with a prescription at most pharmacies, and you may find your Motegrity cost is lower if you order your medication online from Canada.

Fact Table






Over 90%

Legal status


Chemical Name


Elimination half-life

18-20 hours

Dosage (Strength)

1mg, 2mg


Not Recommended



Protein binding


PubChem CID






ATC code






Routes of administration

By mouth (Tablets)


Take 1 Motegrity tablet once a day, with or without food.


The active ingredient in Motegrity is Prucalopride. 


Before beginning on Motegrity, be sure to speak with your doctor if you have any history of have or have had depression, suicidal thoughts or actions, mood changes, kidney problems, or if you are pregnant or plan to become pregnant.


Possibility of drug interaction risks between Motegrity and the following medications and supplements; mitriptyline, atorvastatin, baclofen, Cymbalta (duloxetine), famotidine, gabapentin, levothyroxine, Linzess (linaclotide), Lyrica (pregabalin), MiraLAX (polyethylene glycol 3350), omeprazole, ondansetron, pantoprazole, prednisone, promethazine, tramadol, trazodone, Vitamin B12 (cyanocobalamin), Vitamin D3 (cholecalciferol), and Zyrtec (cetirizine)

Inform your doctor of all medications and supplements you are taking when you consult regarding constipation relief medications for CIC and before proceeding to buy Motegrity medication.

Side Effects

Motegrity side effects are uncommon, but some people may experience headache, abdominal pain or bloating, nausea, diarrhea, dizziness, vomiting, gas, or fatigue.

If Motegrity side effects persist or become severe you should stop using the medication and visit your doctor again regarding chronic constipation treatment options.

Frequently Asked Questions about Motegrity (Prucalopride)

What is Motegrity?

Motegrity, also called prucalopride, is a prescription medication used to treat chronic idiopathic constipation by stimulating natural contractions in the colon.

How does Motegrity work?

Motegrity targets serotonin receptors in the colon to stimulate muscle contractions, aiding in the passage of food through the digestive tract.

What are the most common side effects of Motegrity?

Common side effects include nausea, abdominal pain, headache, and diarrhea.

Why is Motegrity so expensive?

The high cost of Motegrity is due to factors like research, patents, production, distribution, and insurance coverage.

How long does Motegrity stay in your system?

The specific duration of Motegrity in the system is not clearly stated; consult a healthcare provider for accurate information.

How long does it take for Motegrity to start working?

Motegrity typically starts working after the first dose, with bowel movements expected within a few days.

Does Motegrity cause weight gain?

No, weight gain is not a reported side effect in Motegrity studies.

How long can you take Motegrity?

If deemed safe and effective by you and your doctor, Motegrity can be taken long term.

What is the best time of day to take Motegrity?

Motegrity can be taken at any time of day, with or without food.

Can you drink alcohol with Motegrity?

While there are no known interactions between Motegrity and alcohol, your doctor may advise against it due to potential worsening of side effects.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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