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Cymbalta (Duloxetine HCl)

Also Known as Yentreve, Xeristar

Prescription medicineOnly Available By Prescription

Top brand choice

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You'll have option to make 4 interest-free payments by credit card once your order is confirmed using

Top Generic choice

Strength Pack Size Qty
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You'll have option to make 4 interest-free payments by credit card once your order is confirmed using

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Chemical Name DULOXETINE (doo-LOX-e-teen)

CYMBALTA is a prescription serotonin-norepinephrine reuptake inhibitor (SNRI) medication effectively used for the treatment of major depressive disorder (MDD) and generalized anxiety disorder (GAD) mental depression. It is also used for pain caused by nerve damage associated with diabetes, diabetic peripheral neuropathic pain, fibromyalgia and chronic musculoskeletal pain due to chronic osteoarthritis pain and chronic low back pain.

Some patients may think CYMBALTA can be used for stress urinary incontinence; however the FDA failed the approval due to concerns over liver toxicity and suicidal events. In contrast, it is approved for this purpose in Europe, where it is used as an 'add-on' medication in stress urinary incontinence instead of surgery.

Other top related depression drugs available at include Lexapro and Prozac.

Dispensed from a jurisdiction where this item is approved for sale.

Fact Table




FDA approved


Approximately 50% (range 40% to 60%)

Legal status

Prescription only (?-only)

Chemical Name


Elimination half-life

Approximately 12 hours (range 8–17 hours)

Dosage (Strength)

Capsules: 20 mg, 30 mg, 60 mg

Pregnancy advice

Use only if the potential benefit justifies the potential risk to the fetus (Category C)


Cymbalta, Yentreve, and others

Protein binding


PubChem CID






ATC code






Routes of administration



Take CYMBALTA exactly as directed by your health professional. It should be taken orally. Try to take it at the same time daily. Follow the directions on your prescription label.

  • Do not open, break or chew capsule; it must be swallowed whole
  • It can be taken with or without food
  • Do not take in larger or smaller amounts or for longer than recommended
  • Continue using the medication as directed - do not adjust doses without consulting your health professional


Talk to your health professional about the following conditions to make sure you can safely take CYMBALTA:

  • liver or kidney disease
  • seizures or epilepsy
  • bleeding or blood clotting disorder
  • glaucoma
  • bipolar disorder (manic depression)
  • history of drug abuse or suicidal thoughts
  • use of any prescription, nonprescription and herbal medications
  • use of any NSAID pain relievers, aspirin, or blood thinners
  • about your alcohol use
  • your blood pressure
  • if you are pregnant or plan to become pregnant during therapy, or are breast-feeding
CYMBALTA may also increase chances of:
  • suicidal thoughts, especially in patients younger than 24 years old
  • mood changes
  • increased pressure on your eyes (narrow-angled glaucoma)
  • impaired thinking and/or reactions
  • bleeding when taken with other NSAID medications
  • complications in your pregnancy and breastfeeding
  • increased sensitivity to side effects for older patients
  • heightened blood pressure
CYMBALTA is not recommended for patients younger than 18 years old without the advice of a health professional.

The following should be avoided while taking CYMBALTA:

  • drinking alcohol as it may increase the risk of liver damage
  • operating heavy machinery
  • driving
  • any activity that requires you to be alert (until your body has adjusted to the medication)

Side Effects

As with all medications, CYMBALTA has side effects which range from moderate to serious.

Common side effects may include:

  • nausea
  • dry mouth
  • sleepiness
  • fatigue
  • constipation
  • dizziness
  • decreased appetite
  • increased sweating
Stop using CYMBALTA and call your health professional if you experience:
  • itching
  • right upper-belly pain
  • dark urine
  • yellow skin/eyes, or unexplained flu-like symptoms
  • severe liver problems
  • high fever or stiff muscles
  • skin blisters, serious or peeling rash, hives, mouth sores, or any other allergic reaction.
  • confusion, dizziness or fainting upon standing
  • difficulty concentrating, memory problems
  • problems with urine flow
Some of the above symptoms may be cured by changing your dose as recommended by your health professional.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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