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Lonsurf (Trifluridine / Tipiracil)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Lonsurf is a prescription cancer treatment medication designed for slowing metastatic stomach, colon, or rectal cancer. Patients who are unable to take other chemotherapy medications may be prescribed Lonsurf. It is formulated differently with two medicines that prevent cancer cells from making copies of themselves and this slows cancerous tumor growth. Lonsurf is often part of gastric cancer treatment or colorectal cancer treatment, and you can buy Lonsurf online with a prescription at most pharmacies.


Take 1 Lonsurf tablet twice each day, and with meals. Lonsurf dosage is in either 15 or 20mg tablets, and your doctor will determine which one is best for you.

Lonsurf goes on a 28-day treatment schedule; One tablet is taken twice a day for 5 days, and then you rest for 2 days, not taking it. This dosage schedule continues for 2 weeks. After 2 weeks you will not take Lonsurf for 14 days (2 weeks).

This schedule then repeats.


The active ingredients in Lonsurf are Trifluridine and Tipiracil. 


Never exceed Lonsurf dosing guidelines for this gastric and colorectal cancer medication.

Taking Lonsurf may not be safe if you have a history of kidney disease or liver disease.

Do not take Lonsurf if you are pregnant or intend to become pregnant.


Drug interaction risks between Lonsurf and the following medications have been established; acetaminophen, hydrocodone, Actemra (tocilizumab), Adcirca (tadalafil), Adempas (riociguat), aspirin, Avastin (bevacizumab), Benadryl Allergy (diphenhydramine), capecitabine, doxycycline, enoxaparin, gabapentin, lisinopril, Lomotil (atropine, diphenoxylate), losartan, Norvasc (amlodipine), omeprazole, testosterone, Xanax (alprazolam), and Zofran (ondansetron)

Inform your doctor of all medications and supplements you are taking when you speak with them regarding cancer treatment medications and before proceeding to buy Lonsurf online.

Side Effects

Lonsurf side effects are uncommon, but some people may experience tiredness (fatigue/weakness), nausea, vomiting, decreased appetite, diarrhea, abdominal pain, or fever.

If Lonsurf side effects persist or become severe you should stop medication use and talk to your doctor again regarding gastric and colorectal cancer medication and treatment options.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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