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Adcirca (Tadalafil)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Adcirca is an oral medication used to treat pulmonary arterial hypertension (PAH). PAH is a chronic condition where the cells of the lungs are not receiving enough blood flow. Symptoms include chest pressure, pain, fatigue, dizziness, shortness of breath, and swelling in the ankles or legs.

Adcirca works by relaxing the blood vessels in the lungs. Relaxing the vessels increases oxygen delivery and prevents blood from pooling in the lungs.

Fact Table







Legal status


Chemical Name


Elimination half-life

17.5 hours

Dosage (Strength)





Cialis, Cidala, Adcirca

Protein binding


PubChem CID






ATC code






Routes of administration

by mouth


Take Adcirca exactly as directed by your doctor. It is available in 20 mg tablets, and the usual dose is 40 mg by mouth once daily. It is not recommended to split the dosage multiple times per day.

Adcirca can be taken with or without food.


The active ingredient in Adcirca generic is tadalafil.


Adcirca can interact with many different medications, including:

  • Abametapir
  • Alprostadil
  • Amyl nitrate
  • Apalutamide
  • Atazanavir
  • Carbamazepine
  • Ceritinib
  • Clarithromycin
  • Dapoxetine
  • Darunavir
  • Enzalutamide
  • Fosamprenavir
  • Fosphenytoin
  • Fusidic acid
  • Idelalisib
  • Indinavir
  • Itraconazole
  • Ketoconazole
  • Lonafarnib
  • Lopinavir
  • Lumacaftor
  • Lumacaftor-ivacaftor
  • Mifepristone
  • Mitotane
  • Nefazodone
  • Nelfinavir
  • Nitroprusside
  • Ombitasvir-paritaprevir-ritonavir
  • Organic nitrates (vasodilators)
  • Phenobarbital
  • Phenytoin
  • Posaconazole
  • Primidone
  • Rifampin (rifampicin)
  • Riociguat
  • Ritonavir
  • Saquinavir
  • Telithromycin
  • Tucatinib
  • Voriconazole

Tell your doctor and pharmacist about all medications you are taking, including over-the-counter (OTCs), supplements, and herbal medications. 


Adcirca has the potential for life-threatening drug interactions and should not be taken with organic nitrates or guanylate cyclase stimulators (GCs).

Use caution if you have a history of low blood pressure or liver problems.

Tell your doctor right away if you experience vision problems, hearing loss, or prolonged erection while taking this medication.

Side Effects

Common adverse reactions may include:

  • Back pain
  • Diaphoresis
  • Dizziness
  • Dyspepsia
  • Flushing
  • Headache
  • Hearing loss
  • Hypertension
  • Increased liver enzymes
  • Limb pain
  • Myalgia
  • Nasal congestion
  • Nasopharyngitis
  • Nausea
  • Prolonged erection
  • Rectal hemorrhage
  • Renal insufficiency
  • Respiratory tract infection
  • Skin rash
  • Tinnitus
  • Urinary tract infection


Adcirca [package insert]. Indianapolis, IN: Eli Lilly; 2020.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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