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Jentadueto (Linagliptan / Metformin)

Also Known as Trajentamet

Prescription medicineOnly Available By Prescription

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You'll have option to make 4 interest-free payments by credit card once your order is confirmed using

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


If you have type 2 diabetes mellitus, your doctor may prescribe Jentadueto in combination with diet and exercise. This medication is not effective for people with type 1 diabetes mellitus.

Type 2 diabetes is a chronic condition recognized with blood testing, but you should tell your doctor if you have unexplained weight loss, excessive thirst, excessive urination, or fatigue.


Jentadueto is taken by mouth twice daily. Do not adjust the medication without speaking with your healthcare provider.


Jentadueto is a combination drug that contains metformin and linagliptin.

Linagliptin is a DPP4 inhibitor, which means that it can increase certain enzymes in the gastrointestinal tract that affect glucose processing. It ultimately increases levels of insulin and decreases levels of glucose.

Metformin works in the liver to lower the amount of glucose it makes. It also makes other cells of the body more sensitive to insulin.


Jentadueto can interact with the following drugs:

  • Alcohol 
  • Apalutamide
  • Carbamazepine
  • Clotrimazole
  • Dexamethasone
  • Dolutegravir
  • Enzalutamide
  • Fosamprenavir
  • Fosphenytoin
  • Glimepiride
  • Glipizide
  • Glyburide
  • Indinavir
  • Insulins
  • Iodinated Contrast Agents
  • Lumacaftor-ivacaftor
  • Mitotane
  • Morphine 
  • Nelfinavir
  • Phenobarbital
  • Phenothiazines
  • Phenytoin
  • Phenytoin
  • Prazosin
  • Primidone
  • Ranolazine
  • Retinoic acid 
  • Rifampin (rifampicin)
  • Ritonavir 
  • Saquinavir
  • Spironolactone
  • St. John's Wort

Since many drugs (including over-the-counter and supplements) can affect diabetes care, it is important to tell your doctor and pharmacist about all drugs you are taking.


Once you are prescribed then buy Jentadueto, tell your doctor if you develop edema (swelling) or serious skin reactions after starting this medication.

Jendadueto may increase the risk of lactic acidosis in some patients. Tell your doctor if you have a history of this condition.

Side Effects

Common Jentadueto side effects can include:

  • Abdominal distress
  • Abdominal pain
  • Asthenia
  • Cough
  • Diarrhea
  • Dyspepsia
  • Flatulence
  • Flushing
  • Headache
  • Increased serum lipase 
  • Increased uric acid
  • Low blood sugar
  • Low vitamin B12
  • Nasopharyngitis
  • Nausea
  • Palpitations
  • Vomiting


Jentadueto [package insert]. Indianapolis, IN: Boehringer; 2016.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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