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Indocin (Indomethacin)

Prescription medicineOnly Available By Prescription

Top Generic choice

Strength Pack Size Qty
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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Indomethacin is used for the treatment of:

Indomethacin belongs to the class of medication Non-Steroidal Anti-inflammatory Drugs (NSAIDs). NSAIDs are a type of pain medications that are non-narcotic. Indomethacin should be used for the shortest time possible and at the lowest dose to minimize the risk of side effects.

Fact Table







Legal status


Chemical Name


Elimination half-life

2.6-11.2 hours

Dosage (Strength)

25mg, 50mg


Not Recommended


Indocid, Indocin

Protein binding


PubChem CID






ATC code






Routes of administration

By mouth


Take indomethacin exactly as directed by your physician. Example dosages are below:

  • Moderate to severe rheumatoid arthritis including acute flares of chronic disease: 25 mg by mouth two to three times daily.
  • Moderate to severe ankylosing spondylitis: 25 mg by mouth two to three times daily.
  • Moderate to severe osteoarthritis: 25 mg by mouth two to three times daily.
  • Acute painful shoulder: 75-150 mg two to three times daily.
  • Acute gouty arthritis: 50 mg three times daily.


The active ingredient in indomethacin is indomethacin; it is available as a generic prescription.


 Common drug interactions with indomethacin include:

  • Acemetacin
  • Aminolevulinic Acid
  • Apixaban
  • Bemiparin
  • CycloSPORINE 
  • Dabigatran Etexilate
  • Diflunisal
  • Edoxaban
  • Enoxaparin
  • Heparin
  • Ketorolac
  • Lithium
  • Loop Diuretics
  • Macimorelin
  • Methotrexate
  • Mifamurtide
  • Nonsteroidal Anti-Inflammatory Agents
  • Phenylbutazone
  • PRALAtrexate
  • Rivaroxaban
  • Salicylates
  • Selective Serotonin Reuptake Inhibitors
  • Sincalide
  • Sodium Phosphates
  • Tenofovir Products
  • Tenoxicam
  • Tiludronate
  • Triamterene
  • Urokinase
  • Vitamin K Antagonists


Tell your doctor if you have a history of high blood pressure, kidney problems, or liver problems. 

Avoid this medication if you have a history of heart failure.

Ask your doctor and pharmacist for a full list of precautions. 

Side Effects

Common indomethacin side effects may include:

  • Abdominal distress
  • Abdominal pain
  • Alopecia
  • Anorexia
  • Bloating
  • Chest pain
  • Constipation
  • Decreased appetite
  • Depression
  • Diaphoresis
  • Diarrhea
  • Dizziness
  • Drowsiness
  • Dyspepsia
  • Epigastric pain
  • Fatigue
  • Gastroenteritis
  • Headache
  • Heartburn
  • Hot flash
  • Hyperhidrosis
  • Hypertension
  • Malaise
  • Nausea
  • Pancreatitis
  • Postoperative hemorrhage
  • Presyncope
  • Pruritus
  • Skin Rash
  • Swelling
  • Syncope
  • Tinnitus
  • Vertigo
  • Vomiting


Indomethacin, Philadelphia, PA: Iroko Pharmaceuticals, LLC; 2016.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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