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Cortef (Hydrocortisone)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Cortef (hydrocortisone) is a steroid medication. It is typically used to treat;inflammation, but it also has immunosuppressive and antiproliferative effects. Cortef works by decreasing your body's ability to produce its natural inflammatory chemicals. It also reduces your body's ability to mobilize white blood cells, which results in reduced inflammation. You can buy Cortef online as 5mg, 10mg, or 20mg tablets. You can also buy Cortef generic tablets. Store your Cortef or hydrocortisone tablets at room temperature and keep them out of reach of children.

Fact Table







Legal status

US: RX Only

Chemical Name


Elimination half-life


Dosage (Strength)



Consult Doctor


A-hydrocort, Cortef, Solu-cortef

Protein binding


PubChem CID






ATC code






Routes of administration

By mouth (tablets), intravenous, topical, rectal


  • Take your Cortef without regard to meals. If your doctor prescribes a high dose, they should instruct you to take it with food to decrease adverse effects.
  • Your doctor should monitor your therapy and adjust your dose as needed.
  • Do not abruptly stop taking Cortef unless instructed. You should slowly taper your dose down. Ask your doctor for specific instructions.
  • The usual dose of Cortef is anywhere from 20mg to 240mg per day.
    • Your doctor could start you at a high dose and decrease it or increase it as your therapy continues.


  • The active ingredient of Cortef and Cortef generic is hydrocortisone.
  • For a full list of inactive ingredients, see the package insert.


  • Do not take Cortef if you have a known allergy to any of the ingredients.
  • Do not use Cortef if you have an active fungal infection.
  • Cortef can increase your blood pressure. Talk to your doctor about your risk.
  • Avoid live vaccines while using Cortef. Talk to your doctor or pharmacist about alternative vaccine choices.
  • Do not get a smallpox vaccine while using Cortef.
  • Cortef can decrease your response to vaccines.
  • Using Cortef can cause changes in your calcium and potassium levels. Your doctor could prescribe nutritional supplements.
  • Cortef can increase your risk of infection and can also hide the symptoms.
  • Cortef therapy can lead to tuberculosis reactivation. Tell your doctor if you have ever had tuberculosis.
  • Tell your doctor if you suffer from emotional instability or psychotic tendencies. Your risk of psychic disturbances could be increased by Cortef.
  • Tell your doctor if you have any of the following conditions before starting Cortef:

Side Effects

  • Osteoporosis
  • Psychotic disorder
  • Fluid retention
  • Electrolyte changes
  • Increased blood pressure
  • Muscle weakness
  • Muscle pain
  • Decreased muscle mass
  • Increased liver enzymes
  • Impaired wound healing
  • Vertigo
  • Headache
  • Suppression of growth in children
  • Menstrual irregularities
  • Manifestation of latent diabetes
  • Cushing's syndrome
  • High blood sugar
  • Tendon rupture
  • Vertebral compression fracture
  • Aseptic necrosis of femoral and humeral heads
  • Fracture of long bones
  • Peptic ulcer
  • Pancreatitis
  • Abdominal distention
  • Ulcerative esophagitis
  • Convulsions
  • Elevated cerebral pressure
  • Adrenocortical and pituitary unresponsiveness
  • Pheochromocytoma
  • Pulmonary tuberculosis
  • Leukocytosis


  1. DailyMed - CORTEF- hydrocortisone tablet. (2019). Retrieved April 05, 2020
  2. Cortef. (n.d.). Retrieved April 05, 2020

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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