Zyflo CR (Ziluton)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Zyflo CR (zileuton) is a medication used to prevent and treat asthma in adults and children who are 12 years old or older.

Zyflo CR is not indicated for the treatment of a sudden asthma attack.

Zyflo CR is classified as a leukotriene synthesis inhibitor.

Fact Table




US FDA, US DailyMed


Not yet established

Legal status


Chemical Name


Elimination half-life

2.5 hours

Dosage (Strength)



Consult doctor



Protein binding


PubChem CID






ATC code






Routes of administration



The instructions that are supplied with your Zyflo CR prescription should be followed. Refer any questions or concerns to your doctor or pharmacist.

Zyflo CR comes in a 600 mg extended-release tablet. 

The recommended dose is two tablets by mouth two times a day, within one hour after breakfast and dinner. 


Zileuton is the active ingredient contained in Zyflo CR tablets. Crospovidone, ferric oxide, glyceryl behenate, hydroxypropyl cellulose, hypromellose, magnesium stearate, mannitol, microcrystalline cellulose, povidone, pregelatinized starch, propylene glycol, sodium starch glycolate, and talc are the inactive ingredients.


Patients with liver disease or liver function enzymes that are consistently 3 times or more than the upper normal limit should avoid taking Zyflo CR.

Patients with an allergy or sensitivity to zileuton or any of the other ingredients in Zyflo CR should avoid taking Zyflo CR.


  • Before taking Zyflo CR, patients should tell their doctor about their allergies and medical conditions, in addition to all the medications they take and their pregnancy or breastfeeding status. 
  • Liver function enzymes and bilirubin may increase with the use of Zyflo CR. Patients should use caution if they drink alcohol and/or have or have had liver disease.
  • Sleep problems and behavior changes can be caused by Zyflo CR. Patients should be on the lookout for these effects.

Side Effects

Sinusitis, nausea, and pharyngolaryngeal pain are the most common side effects that occur with Zyflo CR. Zyflo CR can cause other side effects as well, so patients should call their doctor if they experience side effects that bother them or won't go away. 


  1. Zyflo CR (zileuton) extended-release tablets. Cary, NC: Chiesi USA, Inc.; 2018.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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