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Zuplenz (Ondansetron)

Prescription medicineOnly Available By Prescription

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You'll have option to make 4 interest-free payments by credit card once your order is confirmed using

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Zuplenz is a prescription antiemetic medication used to prevent nausea and vomiting resulting from chemotherapy, radiation treatments, or occurring post-op following a surgery. Ondansetron is the active ingredient in Zuplenz and it functions by blocking serotonin from the brain so that it’s not able to cause nausea and vomiting. The medication is taken differently depending on if it is for prevention of nausea and vomiting from chemotherapy or from radiation therapy. When it is taken to prevent nausea after surgery it must be taken 1 hour before the surgery.

You can buy Zuplenz with a doctor’s prescription at our local pharmacy, but your lowest Zuplenz cost will be when your order medication online from Canada Drugs Direct.


  1. Follow dosage guidelines as indicated in your prescription and reflecting your usage of the medication.
  2. Remove a single film and place it on the top of your tongue.
  3. Allow dose to dissolve completely before swallowing.
  4. If your indicated dosage is for more than one film, allow each film to dissolve completely before putting the next one in your mouth.
  5. Wash your hands after taking this medication.

Zuplenz can be taken up to three (3) times per day for one (1) to two (2) days after each chemotherapy and radiation treatment.


The active ingredient in Zuplenz is Ondansetron.


Inform your doctor of any history of irregular heartbeat, liver or stomach / intestinal programs before starting on Zuplenz.

Ondansetron can be a cause of a heart condition - QT prolongation - that affects heart rhythm and can be a serious health risk for some people. Advise your doctor of all medications you are currently taking and if you have any history of heart failure, slow heartbeat, QT prolongation in EKG, or cardiac arrest. Low levels of potassium may also contribute to QT prolongation.

Only use medication during pregnancy or when breastfeeding if approved by a doctor.


The possibility of negative drug interaction risk exists between Zuplenz and other Rx medications including dofetilide, pimozide, procainamide, amiodarone, quinidine, Sotalol, macrolide antibiotics like erythromycin, SSRi and SSNi antidepressants, along with major toxicity risks if paired with non-prescription street drugs like MDMA.

Tell your doctor of all medications you are currently taking before getting a prescription and going to buy Zuplenz online.

Side Effects

Zuplenz side effects are rare, but some users may experience headache, light headedness, dizziness, tiredness, or constipation. If you have Zuplenz side effects, then stop medication use and meet with your doctor again to discuss other nausea and vomiting relief alternatives.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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