Zorvolex (diclofenac)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Zorvolex is a prescription NSAID used to treat mild to moderate pain in adults. It is usually only used for a short period. Long-term usage can increase the risk of side effects.

Fact Table







Legal status


Chemical Name


Elimination half-life

1.2–2 h

Dosage (Strength)

18mg, 35mg


Consult Doctor



Protein binding

More than 99%

PubChem CID






ATC code






Routes of administration

By mouth, rectal, intramuscular, intravenous, topical


The usual dosage is 18-35 mg by mouth once daily with food.


The active ingredient in Zorvolex is diclofenac.


Drug-drug interactions can include:

  • Abrocitinib
  • Acemetacin
  • Aminolevulinic Acid
  • Apixaban
  • Bemiparin
  • Cyclosporine
  • Dabigatran Etexilate
  • Deferiprone
  • Edoxaban
  • Enoxaparin
  • Heparin
  • Ketorolac
  • Lithium
  • Loop Diuretics
  • Macimorelin
  • Methotrexate
  • Mifamurtide
  • Nonsteroidal Anti-Inflammatory Agents
  • Nonsteroidal Anti-Inflammatory Agents
  • Phenylbutazone
  • Pralatrexate
  • Rivaroxaban
  • Salicylates
  • Selective Serotonin Reuptake Inhibitors
  • Sincalide
  • Sodium Phosphates
  • Tenofovir Products
  • Tenoxicam
  • Urokinase
  • Vitamin K Antagonists


Tell your doctor if you have a history of heart disease, gastrointestinal disease, liver dysfunction, kidney problems, edema, or skin conditions before starting this drug.

Side Effects

Common side effects may include:

  • Abdominal pain 
  • Abnormal dreams
  • Acute myocardial infarction
  • Agranulocytosis
  • Alopecia
  • Anaphylaxis
  • Anemia
  • Angioedema
  • Anxiety
  • Aplastic anemia
  • Asthenia
  • Asthma
  • Auditory impairment
  • Back pain 
  • Blurred vision
  • Cardiac arrhythmia
  • Cardiac failure
  • Cerebrovascular accident
  • Change in appetite
  • Colitis
  • Coma
  • Confusion
  • Conjunctivitis
  • Constipation 
  • Coronary thrombosis
  • Cystitis
  • Depression
  • Diaphoresis 
  • Diarrhea
  • Dizziness 
  • Drowsiness 
  • Duodenal ulcer
  • Dyspepsia 
  • Dyspnea
  • Dysuria
  • Ecchymoses
  • Edema 
  • Eosinophilia
  • Eructation
  • Erythema multiforme
  • Esophagitis
  • Exfoliative dermatitis
  • Fever
  • Flatulence 
  • Fluid retention
  • Flushing
  • Fulminant hepatitis
  • Gastric ulcer
  • Gastritis
  • Gastrointestinal hemorrhage
  • Gastrointestinal inflammation
  • Gastrointestinal perforation
  • Glossitis
  • Hallucination
  • Headache 
  • Heartburn
  • Hematemesis
  • Hematuria
  • Hemolytic anemia
  • Hepatic failure
  • Hepatic necrosis
  • Hepatitis
  • Hepatotoxicity
  • Hyperglycemia
  • Hypertension 
  • Hypotension
  • Increased liver enzymes
  • Increased serum alanine aminotransferase 
  • Increased serum aspartate aminotransferase
  • Increased serum creatinine 
  • Infection
  • Insomnia
  • Interstitial nephritis
  • Jaundice
  • Leukopenia
  • Limb pain 
  • Lymphadenopathy
  • Malaise
  • Melena
  • Meningitis
  • Musculoskeletal pain 
  • Nausea 
  • Necrolysis
  • Nervousness
  • Oliguria
  • Palpitations
  • Pancreatitis
  • Pancytopenia
  • Paresthesia
  • Peptic ulcer
  • Pneumonia
  • Polyuria
  • Prolonged bleeding time
  • Proteinuria
  • Pruritus 
  • Purpuric disease
  • Rectal hemorrhage
  • Renal failure syndrome
  • Renal function abnormality
  • Renal papillary necrosis
  • Respiratory depression
  • Seizure 
  • Sepsis
  • Sinusitis 
  • Skin photosensitivity
  • Skin rash
  • Stevens-Johnson syndrome
  • Stomatitis
  • Syncope
  • Tachycardia
  • Thrombocytopenia
  • Tinnitus
  • Toxic epidermal 
  • Tremor
  • Upper abdominal pain 
  • Urticaria
  • Vasculitis
  • Vertigo
  • Vomiting 
  • Weight changes
  • Xerostomia


Zorvolex. Philadelphia, PA: Iroko Pharmaceuticals, LLC; 2013.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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