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Zortress (Everolimus)

Also Known as Certican

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Zortress (everolimus) is a medication prescribed to prevent organ rejection in kidney or liver transplant adult patients.

Zortress comes in 0.25 mg, 0.5 mg, 0.75 mg, and 1 mg tablets to be taken by mouth.

Fact Table






Everolimus is well absorbed orally, with a bioavailability of approximately 30% to 40%

Legal status


Chemical Name


Elimination half-life

The elimination half-life of everolimus ranges from approximately 30 to 60 hours.

Dosage (Strength)

0.25 mg to 1 mg


Consult Doctor


Zortress is one of the brand names for everolimus. It may also be sold under other brand names, such as Afinitor

Protein binding

Everolimus is highly bound to plasma proteins, with approximately 74% to 77% protein binding

PubChem CID






ATC code






Routes of administration

By Mouth


Zortress should be taken as prescribed by your doctor. Any questions or concerns can be answered by your doctor or pharmacist.

Recommended Starting Dose

For kidney transplantation:

Take 0.75 mg orally twice daily. Start taking it as soon as possible after the transplant.

For liver plantation:

Take 1 mg orally twice daily. Start taking it 30 days after the transplant.

Patients who have liver function problems may need a lower dose.


Everolimus is the active ingredient in Zortress. Butylated hydroxytoluene, magnesium stearate, lactose monohydrate, hypromellose, crospovidone, and lactose anhydrous are the inactive ingredients included.


If you have an allergy to everolimus, sirolimus, or to any of the other ingredients in the medication, you should not take Zortress.


The following FDA Boxed Warning is associated with Zortress:

  • Zortress should only be prescribed by physicians who have experience in immunosuppressive therapy and management of transplant patients
  • Immunosuppression caused by Zortress can increase the risk of infection and malignancies
  • Kidney graft thrombosis may occur more often
  • When taking cyclosporine with Zortress, the dose of cyclosporine should be reduced to prevent kidney problems
  • Zortress is not recommended for use in heart transplantation, as there has been increased mortality in a clinical trial
  • Before starting treatment with Zortress, talk to your doctor about:
    • All prescription and nonprescription medications you take
    • Any allergies you may have
    • Your past medical history and current health issues
    • Your pregnancy status
    • Your breastfeeding status
  • Angioedema, or swelling underneath the skin, may be caused by Zortress. The risk is increased if you take Zortress with other medications that can cause angioedema, including blood pressure medications like angiotensin converting enzyme (ACE) inhibitors.
  • Wounds may have a longer healing time and wound-related complications may occur more frequently with Zortress use.
  • Some patients taking Zortress have experienced interstitial lung disease.
  • Zortress may cause an increase in cholesterol and triglyceride levels.
  • Protein may be present in the urine while taking Zortress.
  • An increased risk for opportunistic infections such as polyoma virus infections may be caused by Zortress.
  • An increased risk of thrombotic microangiopathy (TMA)/thrombotic thrombocytopenic purpura (TTP)/hemolytic uremic syndrome (HUS) may be caused by taking Zortress with cyclosporine.
  • An increased risk of diabetes after transplant may be caused by Zortress. Closely monitor blood sugar levels.
  • A fetus may be harmed by Zortress. Women are recommended to use effective contraception during treatment and for 8 weeks after taking the last dose.
  • Male infertility may be caused by Zortress.
  • Live vaccines should not be administered to patients who take Zortress.
  • Grapefruit or grapefruit juice should not be consumed while taking Zortress with cyclosporine or tacrolimus.
  • If you have rare hereditary disorders of galactose intolerance such as Lapp lactase deficiency or glucose-galactose malabsorption, you should avoid taking Zortress.

Side Effects

Some, but not all, side effects associated with Zortress include the following: swelling, constipation, high blood pressure, nausea, anemia, urinary tract infection, elevated lipid levels, diarrhea, headache, fever, stomach pain, low white blood cell count, and high cholesterol levels. Immediately talk to your doctor if you develop bothersome or persistent side effects.

Looking to buy Zortress online at a competitive price? With a valid prescription from your doctor, you can find a competitive Zortress cost at Canada Drugs Direct.


Zortress. East Hanover, NJ: Novartis Pharmaceuticals Corporation; 2021.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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