Zoloft (Sertraline)

Also Known as Lustral, Daxid

Prescription medicineOnly Available By Prescription
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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Zoloft, a selective serotonin reuptake inhibitor (SSRI), is a medication available by prescription only to treat:

  • Major depressive disorder (MDD)
  • Obsessive-compulsive disorder (OCD)
  • Panic disorder (PD)
  • Post-traumatic stress disorder (PTSD)
  • Social anxiety disorder (SAD)
  • Premenstrual dysphoric disorder (PMDD)

Sertraline is Zoloft’s generic name.

Zoloft comes in 25 mg, 50 mg, and 100 mg tablets for oral administration as well as an oral solution that contains 20 mg of sertraline per 1 milliliter.


Fact Table

Formula

C17H17Cl2N

License

US FDA

Bioavailability

44%

Legal status

US: RX Only

Chemical Name

Sertraline

Elimination half-life

23–26 hours (66 hours in less-active metabolite, norsertraline)

Dosage (Strength)

25mg (100 tablets), 50mg (28 or 84 tablets), 100mg (84 tablets)

Pregnancy

Consult a doctor

Brands

Zoloft

Protein binding

98.5%

PubChem CID

68617

MedlinePlus

a697048

ChEBI

9123

ATC code

N06AB06

DrugBank

DB01104

KEGG

D02360

Routes of administration

Topical

Directions

Zoloft should be taken exactly as your doctor has instructed. Discuss any questions or concerns with your doctor or pharmacist.

Each patient's dose of Zoloft is based on their age and condition being treated:

Adults

Condition

Recommended 

Starting Dose

Recommended Maintenance Dose

MDD, OCD

50 mg by mouth daily

Up to 200 mg by mouth daily

PD, PTSD, SAD

25 mg by mouth daily

Up to 200 mg by mouth daily

PMDD Continuous Dosing

50 mg by mouth daily

Up to 150 mg by mouth daily

PMDD Intermittent Dosing

50 mg by mouth daily during luteal phase

Up to 100 mg by mouth daily during luteal phase


Pediatrics

Condition

Recommended Starting Dose

Recommended Maintenance Dose

OCD in pediatric patients 6-12 years old

25 mg by mouth daily

Up to 200 mg by mouth daily

OCD in pediatric patients 13-17 years old

50 mg by mouth daily

Up to 200 mg by mouth daily

Ingredients

Sertraline is the active ingredient in Zoloft. 

Inactive ingredients include dibasic calcium phosphate dihydrate, D and C Yellow #10 aluminum lake (in 25 mg tablet), FD and C Blue #1 aluminum lake (in 25 mg tablet), FD and C Red #40 aluminum lake (in 25 mg tablet), FD and C Blue #2 aluminum lake (in 50 mg tablet), hydroxypropyl cellulose, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80, sodium starch glycolate, synthetic yellow iron oxide (in 100 mg tablet), and titanium dioxide. 

Inactive ingredients in Zoloft oral solution include glycerin, alcohol (12%), menthol, butylated hydroxytoluene (BHT). Dry natural rubber makes up the dispenser.

Contraindications

Zoloft should not be taken with monoamine oxidase inhibitors (MAOIs). In addition, patients who have taken an MAOI within the past 14 days should not take Zoloft. 

Zoloft should not be administered to patients who take pimozide or who are allergic to sertraline or to any of the medication's other ingredients.

Patients who are taking disulfiram should not take the Zoloft oral solution.

Cautions

Zoloft (sertraline) contains an FDA Boxed Warning regarding an increased risk of suicidal thoughts and behaviors. Patients should be monitored for signs of suicidal thoughts and behaviors.

  • Before you start taking Zoloft, it’s important that you discuss the following with your doctor:
    • Your prescription and nonprescription medications that you take.
    • Your allergies.
    • Your current health problems and past medical history.
    • Your pregnancy or breastfeeding status.
  • Taking SSRIs can increase the risk of serotonin syndrome, even if they are taken by themselves. There is also a risk when taking SSRIs with triptans, serotonin norepinephrine reuptake inhibitors, or other medications that can cause serotonin syndrome. Talk to your doctor if you are not sure whether or not you take any of these medications.
  • Taking Zoloft with medications such as aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, and warfarin can increase the risk of bleeding.
  • Patients with bipolar disorder may experience a mixed/manic episode during treatment with Zoloft.
  • Zoloft should be used with caution in patients who have seizures.
  • Zoloft should be avoided in patients with untreated narrow angles.
  • Zoloft should be used with caution in patients at risk for QTc prolongation.
  • Sexual dysfunction such as ejaculation issues, decreased desire for sex, and erectile dysfunction can occur with Zoloft use.

Side Effects

Nausea, diarrhea, tremor, indigestion, decreased appetite, excessive sweating, ejaculation failure, and decreased desire for sex are common Zoloft side effects; however, patients may experience other side effects during treatment. Call your doctor immediately if you have bothersome or persistent side effects.

Reference:

Zoloft (sertraline hydrochloride). New York, NY: Roerig; 2021.




IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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