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Strength
40000 Unit
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Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.
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A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Zenpep is a prescription pancreatic enzyme replacement therapy (PERT) indicated for the treatment of exocrine pancreatic insufficiency (EPI) due to conditions such as cystic fibrosis, chronic pancreatitis, pancreatectomy, or other pancreatic disorders. Zenpep contains a combination of porcine-derived lipase, amylase, and protease to aid in the digestion of fats, carbohydrates, and proteins. Delivered in delayed-release capsules, Zenpep is formulated to resist gastric acid and release enzymes in the small intestine, where nutrient absorption occurs. By supplementing deficient digestive enzymes, Zenpep helps improve nutritional status, reduce gastrointestinal symptoms, and support weight gain in patients with EPI.
| Fact Table | |
| Formula | Mixture: Amylase, Lipase, Protease (porcine-derived) |
| License | US FDA |
| Bioavailability | Site-specific (small intestine); not systemically absorbed |
| Legal status | Prescription only (Rx) |
| Chemical Name | Pancrelipase (porcine pancreatic extract) |
| Elimination half-life | Not systemically absorbed |
| Dosage (Strength) | 3,000 to 40,000 USP units lipase per capsule (various strengths) |
| Pregnancy | Category C – Use if benefits outweigh risks |
| Brands | Zenpep, Creon, Pancreaze, Pertzye, Ultresa, Viokace |
| Protein binding | Not applicable |
| PubChem CID | 24277536 |
| MedlinePlus | a601063 |
| ChEBI | 36221 |
| ATC code | A09AA02 |
| DrugBank | DB00085 |
| KEGG | D01714 |
| Routes of administration | Oral (delayed-release capsules) |
Zenpep should be taken during meals and snacks, with dosage tailored to the individual’s weight, age, diet, and clinical symptoms. Capsules must be swallowed whole with sufficient fluid and should not be crushed or chewed to prevent mucosal irritation. For patients who cannot swallow capsules, contents may be sprinkled onto soft, acidic foods (e.g., applesauce) and consumed immediately without chewing. Dosing typically begins with the lowest effective dose and may be adjusted based on symptom control and stool fat content. Enzyme doses should not exceed maximum recommended limits to avoid complications such as fibrosing colonopathy.
Each Zenpep capsule contains a specific amount of pancrelipase (pancreatic enzymes) expressed as lipase, protease, and amylase. The enzymes are derived from porcine pancreatic glands. Inactive ingredients may include methacrylic acid copolymer, triethyl citrate, medium chain triglycerides, and gelatin capsule components. Zenpep does not contain preservatives.
Zenpep is contraindicated in patients with known hypersensitivity to porcine proteins, pancrelipase, or any component of the formulation. It should not be used in cases of acute pancreatitis or during an acute exacerbation of chronic pancreatitis unless clearly indicated and clinically justified.
Patients should be monitored for the development of fibrosing colonopathy, particularly when consuming high doses over extended periods. Caution is also advised in patients with a history of gout, renal impairment, or hyperuricemia due to the purine content of porcine-derived enzymes. Zenpep should be used under medical supervision with regular evaluation of nutritional status, gastrointestinal symptoms, and growth in pediatric patients. Adequate hydration should be maintained during enzyme therapy.
Common side effects of Zenpep may include:
Less commonly, allergic reactions and serious gastrointestinal complications such as fibrosing colonopathy may occur, especially at high doses. Immediate medical attention is warranted if signs of hypersensitivity or severe abdominal symptoms develop.
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