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Zaroxolyn (Metolazone)

Prescription medicineOnly Available By Prescription

Top Generic choice

Strength Pack Size Qty
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You'll have option to make 4 interest-free payments by credit card once your order is confirmed using

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Zaroxolyn (metolazone) is a diuretic, or fluid pill, that is prescribed to treat edema, or swelling. It may also be prescribed to treat high blood pressure.

Zaroxolyn is available in 2.5 mg, 5 mg, and 10 mg oral tablets.

Fact Table




US DailyMed



Legal status


Chemical Name


Elimination half-life

14 hours

Dosage (Strength)

2.5mg, 5mg


Consult Doctor


Zaroxolyn is one of the brand names for metolazone. It may also be sold under other brand names.

Protein binding

Metolazone is moderately protein-bound, with approximately 40% to 50% binding to plasma proteins

PubChem CID






ATC code






Routes of administration

Metolazone is usually taken orally as a tablet


Zaroxolyn should be taken as directed by your doctor. Any questions or concerns that arise may be answered by your doctor or pharmacist.

Zaroxolyn Dose

High blood pressure: Take 2.5 mg to 5 mg by mouth one time a day, up to 20 mg daily.

Fluid retention: Take 2.5 mg to 10 mg by mouth one time a day, up to 20 mg daily.

A lower dose may be required in older patients.


Metolazone is the active ingredient contained in Zaroxolyn.


Do not take Zaroxolyn if you are:

  • Allergic to metolazone or sulfonamides
  • Unable to produce urine

Zaroxolyn should not be given to patients in a hepatic coma or precoma.


  • Before beginning treatment with Zaroxolyn, tell your doctor:
    • About all the prescription and over-the-counter medications you take
    • About any allergies you have
    • About your current health conditions and past medical history
    • If you are pregnant
    • If you are breastfeeding
    • If you have any upcoming surgeries or procedures
  • Caution should be exercised in patients with diabetes, high cholesterol, high levels of uric acid or gout, low blood pressure, lupus, or liver disease. Caution should also be exercised in patients who have had a sympathectomy.
  • Worsening digitalis toxicity may occur with Zaroxolyn use.
  • Photosensitivity may occur with Zaroxolyn use.
  • Zaroxolyn may cause high calcium, low potassium, low sodium, and low magnesium levels.
  • Zaroxolyn may cause angioedema (swelling underneath the skin) or other allergic reactions.
  • Allergic reactions due to cross-sensitivity may present in patients with a sulfa allergy; however, the risk is low or may not even occur.
  • Lipid and glucose metabolism can be affected by Zaroxolyn.
  • Zaroxolyn may cause sexual dysfunction in males.
  • Patients should monitor their blood pressure regularly, especially if they are also being treated with other blood pressure medications.
  • Zaroxolyn use for high blood pressure should be avoided in patients with primary adrenal insufficiency. A different blood pressure medication or an adjustment of glucocorticoid/mineralocorticoid therapy is recommended in these patients.

Side Effects

Chest pain, depression, dizziness, drowsiness, electrolyte imbalances, glucose in the urine, gout attacks, headache, liver problems, high uric acid levels, joint pain, nerve pain, low blood pressure, pancreatitis, serious skin problems, fainting, and volume depletion are some Zaroxolyn side effects; however, these are not the only side effects that may occur. Contact your doctor if you experience side effects that bother you or won't go away.

You can buy Zaroxolyn online at a competitive price and with a valid prescription from your doctor at Canada Drugs Direct.


  1. Metolazone. Medscape.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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