Canada Drugs Direct

Visiting from Canada?

Want to save up to 80% on your medications? Signup below to be notified if we open a Canadian Online Pharmacy.

I agree to receive email updates from Canada Drugs Direct

Looking for Call us toll free 1-800-500-2897

Zanaflex (Tizanidine HCl)

Prescription medicineOnly Available By Prescription

Top brand choice

Strength Pack Size Qty
Pack Size
Pack Size

You'll have option to make 4 interest-free payments by credit card once your order is confirmed using

Top Generic choice

Strength Pack Size Qty
Pack Size
Pack Size

You'll have option to make 4 interest-free payments by credit card once your order is confirmed using

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Your doctor may prescribe Zanaflex to treat muscle spasms that impact daily activities. 

Zanaflex works by activating alpha-2-adrenergic receptors, causing skeletal muscle cells to relax. Zanaflex works over a short duration, so it should be taken before it is needed.


Zanaflex is available as capsules or tablets. The only strength that is available as either is Zanaflex 4 mg. The other capsule sizes are 2 mg and 6 mg.

The starting dosage is 2 mg every 6-8 hours as needed for muscle spasms. The medication should not be taken more frequently than three times per day.

The maximum dosage is 36 mg per day.

Do not stop taking this medication without discussing it with your doctor first as it can cause withdrawal symptoms.

Zanaflex is not meant to be taken as a long-term medication.


The active ingredient in Zanaflex is Tizanidine


The most common drug-drug interactions include the following medications:

  • Abametapir
  • Amifostine
  • Artemisinin
  • Atazanavir
  • Azelastine
  • Beta-blockers
  • Bromperidol
  • Buprenorphine
  • Ceritinib
  • Ciprofloxacin
  • Ciprofloxacin
  • Enoxacin
  • Ethinyl Estradiol
  • Flunitrazepam
  • Fluvoxamine
  • Mexiletine
  • Mirtazapine
  • Obinutuzumab
  • Opioids
  • Orphenadrine
  • Suvorexant
  • Tacrine
  • Thalidomide
  • Thiabendazole
  • Tricyclic Antidepressants
  • Zileuton

Tell your doctor and pharmacist about all medications you are taking before starting Zanaflex. 


Your doctor should check your liver while taking this medication.

Tell your doctor if you have a history of low blood pressure as Zanaflex has the potential to lower blood pressure even further. 

Tizanidine can cause sedation, especially in older adults over the age of 65.

Side Effects

Zanaflex side effects may include:

  • Abnormal liver tests
  • Asthenia
  • Blurred vision
  • Bradycardia
  • Constipation
  • Delusion
  • Dizziness
  • Drowsiness
  • Dyskinesia
  • Flu-like symptoms
  • Hypotension
  • Infection
  • Nervousness
  • Pharyngitis
  • Rhinitis
  • Speech disturbance
  • Urinary frequency
  • Urinary tract infection
  • Visual hallucination
  • Vomiting
  • Xerostomia


Zanaflex [package insert]. Ardsley, NJ: Acorda; 2013.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

product-reviews Product Reviews