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Zamine (Drospirenone - ethinyl estradiol)

Prescription medicineOnly Available By Prescription

Top Generic choice

Strength Pack Size Qty
21 days
Pack Size
28 days
Pack Size

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Zamine (Drospirenone - ethinyl estradiol) is a combination hormone medication prescribed as a contraceptive. It helps prevent pregnancy by changing the uterine lining and cervical mucus to make it difficult for sperm to reach the egg for fertilization. Zamine may help regulate the menstrual cycle and reduce premenstrual syndrome symptoms.

Fact Table







Legal status


Chemical Name


Elimination half-life

24–27 h

Dosage (Strength)

21 days, 28 days





Protein binding


PubChem CID






ATC code






Routes of administration

By mouth


21-day regimen: Take one Zamine birth control pill every day at the same time for 21 consecutive days, then discontinue for 7 days. Expect withdrawal bleeding within 2-3 days after discontinuation. Resume on the 8th day, aligning with the same weekday the original course began.

28-day regimen: Take one active tablet daily for 21 days and then a hormone-free white tablet for 7 days. Withdrawal bleeding generally starts within 2-3 days after the final active yellow tablet. The next course starts promptly after the last, continuing on the same weekday the initial course initiated.


Each active pill of Zamine contains 3 mg of Drospirenone and 0.03 mg of ethinyl estradiol.


You may need to avoid Zamine if a medical history with any of the following apply:

  • Severely high blood pressure
  • Age over 35 years old
  • Smoking
  • Heart disease
  • Stroke
  • Heart attack
  • Diabetes that affects the blood vessels
  • Kidney or liver disease
  • Cancer of the breast or endometrial lining
  • Migraines with focal aura
  • Abnormal cholesterol levels
  • Known or possible pregnancy


  • Before starting Zamine birth control, tell your doctor about any of the following:
    • Any known allergies you may have.
    • All medications you take, including prescription, over-the-counter medications, and herbal supplements.
    • Existing health problems, including but not limited to diabetes, chronic migraines, or mental disorders like depression.
    • If you are pregnant or plan to become pregnant.
    • If you are breastfeeding or have plans to breastfeed.
  • Zamine might influence your blood sugar levels. Regular monitoring may be required if you have diabetes.
  • Zamine may cause a rise in blood pressure. Regularly track your blood pressure and report any abnormal readings to your healthcare provider.
  • There might be an increased risk of clotting issues with Zamine. Particular risks can include clots in the lungs, heart, intestines, or eyes.
  • If you are prone to clotting issues due to injuries or extended illness, use caution. Consider non-hormonal contraceptive methods until you return to your usual activities.
  • If you experience unexplained severe headaches or an increase in the frequency or intensity of migraines, notify your healthcare provider.
  • Zamine has been linked to vision problems, both minor and severe. If you notice any eye-related concerns, including optic nerve swelling or vascular problems in the eye, seek medical attention right away.
  • Should there be an increase in the occurrence of epileptic seizures, discontinue the medication and contact your healthcare provider.

Side Effects

Common Zamine side effects may include nausea, headaches, breast tenderness, and changes in weight or appetite. Some individuals may experience mood changes, such as increased depression or anxiety. More serious side effects may include blood clots, high blood pressure, or liver problems, although these are rare. Seek immediate medical attention if any unusual or severe side effects occur.

Consult a healthcare provider to understand all potential side effects, drug interactions, and warnings before starting birth control.


Zamine Product Monograph. Toronto, ON: Apotex, Inc.; 2015.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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