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Yosprala ( Aspirin and Omeprazole)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Your doctor may prescribe Yosprala if you have a high risk of death or cardiovascular events. It is commonly used in people with angina or those who have had a prior stroke or heart attack. The risk of a repeat event is very high in these patients, and the aspirin in Yosprala helps reduce the risk.

Aspirin can cause gastric ulcers and other bleeding in the gastrointestinal tract, so omeprazole is in the formulation to reduce the bleed risk.


The usual dosage is one tablet by mouth once daily.

Yosprala is available in two strengths, aspirin/omeprazole 81-40 mg and aspirin/omeprazole 325-40 mg.


The active ingredients are aspirin and omeprazole.


Yosprala drug-drug interactions may include:

  • Acalabrutinib
  • Apixaban
  • Atazanavir
  • Belumosudil
  • Bemiparin
  • Bosutinib
  • Carbonic Anhydrase Inhibitors
  • Cefditoren
  • Cefuroxime
  • Cilostazol
  • Citalopram
  • Clopidogrel
  • CYP2C19 Inducers
  • Dabigatran Etexilate
  • Dacomitinib
  • Dasatinib
  • Delavirdine
  • Dexibuprofen
  • Dexketoprofen
  • Edoxaban
  • Enoxaparin
  • Erlotinib
  • Gefitinib
  • Ginkgo Biloba
  • Heparin
  • Infigratinib
  • Influenza Virus Vaccine
  • Itraconazole
  • Ketoconazole 
  • Ketorolac
  • Ledipasvir
  • Levoketoconazole
  • Macimorelin
  • Methotrexate
  • Nelfinavir
  • Neratinib
  • Nilotinib
  • Nonsteroidal Anti-Inflammatory Agents 
  • Omacetaxine
  • Palbociclib
  • Pazopanib
  • Pexidartinib
  • Posaconazole
  • Pralatrexate
  • Probenecid
  • Rilpivirine
  • Risedronate
  • Rivaroxaban
  • Secretin
  • Selpercatinib
  • Sincalide
  • Sotorasib
  • St John's Wort
  • Sucroferric Oxyhydroxide
  • Sulfinpyrazone
  • Talniflumate
  • Ticagrelor
  • Urokinase
  • Varicella Virus-Containing Vaccines
  • Velpatasvir
  • Vitamin K Antagonists 


Even with omeprazole, Yosprala can increase the risk of gastric ulcers.

Use caution if you have a history of kidney or liver problems.

Tell your doctor if you drink alcohol before starting Yosprala.

Long-term usage of omeprazole can cause deficiencies in vitamin B12, calcium, and other vitamins and minerals.

Ask your doctor and pharmacist about all the potential warnings associated with Yosprala.

Side Effects

The most common Yosprala adverse reactions may include:


Yosprala. Princeton, NJ: Aralez Pharmaceuticals US Inc; 2016.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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