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Xpovio (Selinexor)

Prescription medicineOnly Available By Prescription

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Your doctor may prescribe Xpovio for the management of multiple myeloma. This hematologic malignancy, characterized by an overproduction of malignant plasma cells in the bone marrow, requires specialized treatment.

Xpovio inhibits the Exportin-1 (XPO1) protein, a crucial protein involved in the survival of myeloma cells. By blocking XPO1, Xpovio restricts the proliferation of malignant plasma cells, slowing the progression of multiple myeloma.


Take Xpovia exactly as directed by your healthcare provider.


The active ingredient in Xpovia is selinexor.


The most common drug-drug interactions may include:

  • Antithymocyte Globulin (Equine)
  • Baricitinib
  • BCG (Intravesical)
  • BCG Products
  • Brivudine
  • Chloramphenicol (Ophthalmic)
  • Cladribine
  • CloZAPine
  • COVID-19 Vaccine
  • Deferiprone
  • Dengue Tetravalent Vaccine (Live)
  • Denosumab
  • Desmopressin
  • Deucravacitinib
  • Dipyrone
  • Fexinidazole
  • Filgotinib
  • Inebilizumab
  • Influenza Virus Vaccines
  • Leflunomide
  • Mumps- Rubella- or Varicella-Containing Live Vaccines
  • Nadofaragene Firadenovec
  • Natalizumab
  • Ocrelizumab
  • Ofatumumab
  • Olaparib
  • Pidotimod
  • Pimecrolimus
  • Pneumococcal Vaccines
  • Poliovirus Vaccine (Live/Trivalent/Oral)
  • Polymethylmethacrylate
  • Promazine
  • Rabies Vaccine
  • Ritlecitinib
  • Ropeginterferon Alfa-2b
  • Ruxolitinib (Topical)
  • Sipuleucel-T
  • Sphingosine 1-Phosphate (S1P) Receptor Modulator
  • Tacrolimus (Topical)
  • Talimogene Laherparepvec
  • Tertomotide
  • Tofacitinib
  • Typhoid Vaccine
  • Ublituximab
  • Upadacitinib
  • Vaccines (Inactivated/Non-Replicating)
  • Vaccines (Live)
  • Yellow Fever Vaccine


Tell your doctor about any prior health conditions before starting this medication.

Side Effects

Common adverse reactions may include:

  • Abdominal pain
  • Anemia
  • Anorexia
  • Asthenia
  • Blurred vision
  • Cardiac failure
  • Cataract
  • Constipation
  • Cough
  • Decreased appetite
  • Decreased serum albumin
  • Decreased serum calcium
  • Decreased serum magnesium
  • Decreased serum phosphate
  • Dehydration
  • Diarrhea
  • Dizziness
  • Dysgeusia
  • Dyspnea
  • Edema
  • Epistaxis
  • Falling
  • Fatigue
  • Febrile neutropenia
  • Fever
  • Headache
  • Hemorrhage
  • Herpes virus infection
  • Hyperglycemia
  • Hypokalemia
  • Hyponatremia
  • Hypotension
  • Increased creatinine phosphokinase in blood specimen
  • Increased serum alanine aminotransferase
  • Increased serum aspartate aminotransferase
  • Increased serum bilirubin
  • Increased serum creatinine
  • Increased serum potassium
  • Infection
  • Insomnia
  • Leukopenia
  • Lymphocytopenia
  • Mental status changes
  • Musculoskeletal pain
  • Nausea
  • Neurological signs and symptoms
  • Neutropenia
  • Peripheral sensory neuropathy
  • Pneumonia
  • Sepsis
  • Syncope
  • Thrombocytopenia
  • Upper respiratory tract infection
  • Urinary tract infection
  • Vomiting
  • Weight loss


  1. Xpovio [package insert]. City, ST: Pharma; year.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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