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Xifaxan (Rifaximin)

Also Known as Zaxine,Coldir

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Chemical Name: RIFAXIMIN (rif-AX-i-min)

Xifaxan is used to treat traveler's diarrhea caused by certain bacteria. Xifaxan will not work to treat bloody diarrhea or diarrhea with fever. Xifaxan is a tablet but CANNOT be split.

Dispensed from a jurisdiction where this item is approved for sale. Generic not manufactured by Salix.

Fact Table






Less than 4%

Legal status


Chemical Name


Elimination half-life

6 hours

Dosage (Strength)

200mg, 550mg


Not Recommended



Protein binding


PubChem CID






ATC code






Routes of administration

By mouth (tablets)


Follow the directions for taking this medicine provided by your doctor. This medicine comes with a patient information leaflet. Read it carefully. Ask your doctor, nurse, or pharmacist any questions that you may have about this medicine. This medicine may be taken on an empty stomach or with food. STORE THIS MEDICINE at room temperature between 68 and 77 degrees F (20 and 25 degrees C) in a tightly-closed container away from heat and light. Brief storage between 59 and 86 degrees F (15 and 30 degrees C) is permitted. TO CLEAR UP YOUR INFECTION COMPLETELY, continue taking this medicine for the full course of treatment even if you feel better. Do not miss any doses. IF YOU MISS A DOSE OF THIS MEDICINE, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. DO NOT take 2 doses at once.


SIDE EFFECTS that may occur while taking this medication include vomiting.

Side Effects

Frequently Asked Questions about Xifaxan (Rifaximin)

What is Xifaxan (Rifaximin) used for?

Xifaxan fights gut bacterial infections like E. coli in travelers' diarrhea and diarrhea-predominant IBS in adults. It also lowers cognitive decline risk in adults with liver failure.

What to avoid when taking Xifaxan?

Avoid alcohol, grapefruit, grapefruit juice, and other foods or drinks that could make your symptoms worse. Always listen to your doctor about what to eat.

Does Xifaxan have side effects?

Common side effects include nausea, bloating, and headache, but not everyone gets them. If you notice anything strange, talk to your doctor.

Who should not take Xifaxan?

Don't take Xifaxan if you're allergic to rifaximin or similar drugs. Tell your doctor if you have severe liver disease or diarrhea with fever. Pregnant or breastfeeding? Check with your doctor first.

How long can you stay on Xifaxan?

Finish all doses even if you feel better early. Treatment lasts 3 days for travelers’ diarrhea and 2 weeks for IBS.

How long does Xifaxan stay in your system?

Xifaxan clears from your system within a few hours to a day after the last dose, but it can vary from person to person.

Can I drink alcohol with Xifaxan?

It's best to skip alcohol while taking Xifaxan because it might mess with how the drug works.

Does Xifaxan cause fatigue?

Fatigue (tiredness) is a relatively common side effect among people taking Xifaxan for overt hepatic encephalopathy (HE). It may cause you to feel sleepier than usual or experience a lack of energy.

What drugs interact with Xifaxan?

Xifaxan interacts with drugs like warfarin and cyclosporine, affecting their effectiveness. Always tell your doctor about all medications and supplements you're taking to avoid complications.

Why does Xifaxan cause weight gain?

No, Xifaxan doesn't make you gain weight.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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