Xhance (Fluticasone propionate)

Description

Xhance (Fluticasone propionate) is used in adults to treat chronic rhinosinusitis. This prescription corticosteroid nasal spray reduces symptoms and improves breathing in people with or without nasal polyps. This includes inflammation, swelling, mucus buildup, and irritation in the nasal and sinus tissues, resulting in nasal congestion. It can also reduce polyp size.

Directions

Xhance nasal spray is available as a 16 ml bottle. After priming, it provides 120 metered sprays, each spray delivering 93 mcg of fluticasone propionate. Twice daily use with 186 mcg per dose (one spray for each nostril) is recommended. Therefore, most patients use an Xhance dosage of 372 mcg daily. In some cases, your doctor will prescribe 2 sprays per nostril twice daily, for a total dose of 744 mcg. Keep in mind that the onset time and degree of symptom relief may vary.

You should shake Xhance before each use and prime it before the first administration. Press the bottle 7 times and spray into the air, away from your face. If you have not used Xhance for over 7 days, prime the bottle again, but spray only twice.

To use Xhance effectively, start by inserting the tip of the nosepiece into one nostril. This should form a tight seal between the nosepiece and the nostril. Now, place the flexible mouthpiece into the mouth. Adjust it to maintain a tight seal with your nostril. Proceed to blow into the mouthpiece while pushing the bottle up to activate the spray pump at the same time. Continue to blow through the mouth and do not inhale or exhale through the nose when you spray. However, once you have sprayed, you can breathe normally. Never spray directly on the nasal septum and repeat the process in the other nostril for a full dose.

Ingredients

The active ingredient in Xhance nasal spray is fluticasone propionate.

Inactive ingredients are microcrystalline cellulose, carboxymethylcellulose sodium, dextrose, benzalkonium chloride, polysorbate 80, edetate disodium dihydrate, sodium hydroxide and hydrochloric acid (to adjust pH), and purified water.

Contraindications

People with hypersensitivity to any ingredient in Xhance must not take this drug.

Cautions

• Before taking Xhance, inform your doctor if
  • You have other medical conditions, especially nasal and vision problems, current or past infections, tuberculosis, immune system problems, adrenal gland problems, and osteoporosis.
  • You are taking additional medications. This includes not only prescription medications but also over-the-counter drugs and herbal or vitamin supplements. This avoids serious drug interactions, potentially leading to significantly increased steroid levels in your body. This may include certain HIV drugs, antifungals, or antibiotics.
  • Your allergies. Do not take Xhance if you are allergic to one of its active or inactive ingredients. If you experience allergy symptoms such as rash, itching, swelling, or trouble breathing, contact your doctor immediately.
• Watch for signs of nasal septal perforation (a hole in the nasal cartilage), a rare but serious condition. This may include a whistling sound when breathing or new nasal pain. Schedule regular check-ups with your doctor during long-term use.
• Watch for candida (yeast) infections in your nose, throat, or mouth, and report redness, soreness, or white patches to your doctor.
• Do not use Xhance nasal spray if you recently had nasal surgery, sustained a nasal injury or have an open sore, as this medication can slow the healing process. Do not start this medication until your doctor confirms healing.
• Your risk of developing glaucoma and cataracts may rise when using Xhance. Tell your provider immediately if you notice blurred vision, eye pain, or other vision changes and attend regular eye exams.
• Xhance may impact your immune system and raise your infection risk. Try to limit exposure, and use Xhance with caution. Use this drug with caution or avoid it if you have tuberculosis, fungal infections, ocular herpes, or certain other infections. Contact your doctor if you notice signs of infection, such as fever or fatigue.

• Using Xhance may affect your adrenal glands, especially if you are sensitive to steroids or exceed the recommended dose. You may experience extreme tiredness, weakness, nausea, vomiting, or low blood pressure. Stress and stopping oral steroids may also contribute to reduced adrenal function.

• People at an increased risk for bone loss may need close monitoring or preventive treatment while taking Xhance, since long-term steroid use may decrease bone mineral density. For example, this may impact postmenopausal women, smokers, people with poor nutrition, or those taking certain medications.
• Xhance has not been studied in children. Because corticosteroids may slow growth it is only approved for adults 18 years and older.

Side Effects

Nosebleeds, nasal congestion, redness and irritation of the nasal passages, mild sores or ulcers inside the nose, headaches, sore throat or nose, and swelling in the nose or throat are common when taking Xhance. More serious side effects like eye problems (e.g. glaucoma, cataracts), severe allergic reactions, infections, nasal septal perforation, reduced adrenal function (extreme tiredness, weakness, nausea, low blood pressure), and poor nasal wound healing may also occur.

These are not all possible Xhance side effects. If you experience persistent or severe side effects of Xhance, contact your healthcare provider immediately.

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