Xerese (acyclovir/hydrocortisone) Cream

Prescription medicineOnly Available By Prescription

Top brand choice

Strength Pack Size Qty
5g tube of 5%/1%
Pack Size

You'll have option to make 4 interest-free payments by credit card once your order is confirmed using

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Xerese is a prescription medication for cold sore treatment that works to reduce the size of lesions and speeds up their healing time, plus preventing initial cold sores from becoming ulcerative. Cold sores are ulcerative when they burst and become painful. Most Xerese users can stop the herpes simplex virus from progressing to the point of sores bursting. Xerese cream for cold sores is easy to apply, and is a good choice for anyone who doesn't get sufficient relief from cold sores with OTC products like Anbesol.

You can buy Xerese cream with a prescription at most pharmacies, and you'll get a lower Xerese cream cost when you order medication online from Canada Drugs Direct.


Apply Xerese cold sore cream as soon as you see a cold sore developing.

Wash hands before and after use.

Cream should be applied 5 times a day for the first 5 days. Cream can be applied less frequently after that depending on reduction of cold sore or completely getting rid of cold sores.

Keep skin open and do not cover area with any material after application. Do not apply makeup (lipstick) to lips while treating a cold sore with Xerese.


The active ingredients in Xerese are Acyclovir and Hydrocortisone.



Approved for topical use in and around the mouth, do not apply anywhere else on the body.

For ages 6 and up.

Use with caution if pregnant or nursing and discuss with your doctor before beginning on Xerese.

Avoid using other skin care products (including sunscreen) on affected areas while using Xerese as a cold sore treatment.

Never exceed maximum dosage regulation of 5 applications per day. Speak with your doctor again if you think Xerese is not working effectively for you.


The possibility of drug interactions exist between Xerese and certain RX medications - Acetaminophen / Tramadol / Alprazolam amoxicillin / Clavulanate / Augmentin (amoxicillin / clavulanate) / Azithromycin / baclofen / Benadryl (diphenhydramine) / Bupropion / Cetirizine / Clonazepam / Cymbalta (duloxetine) / Diflucan (fluconazole) / Flexeril (cyclobenzaprine) / Hydrocortisone Topical / Magnesium Citrate / Synthroid (levothyroxine) / Tylenol with Codeine #3 (acetaminophen / codeine) / Valacyclovir / Valtrex (valacyclovir) / Zolpidem.

Before you get a prescription to buy Xerese cream, inform your doctor of all medications you are currently on.

Side Effects

It is uncommon to see side effects from Xerese, but some people may have drying or flaking skin, burning, tingling, erythema, pigmentation changes, or skin inflammation. If you experience any of these uncommon side effects, then discontinue use and speak with your doctor for other cold sore treatment options.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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