Canada Drugs Direct

Visiting from Canada?

Want to save up to 80% on your medications? Signup below to be notified if we open a Canadian Online Pharmacy.

I agree to receive email updates from Canada Drugs Direct

Looking for CanadaDrugsDirect.net? Call us toll free 1-800-500-2897

Xarelto (Rivaroxaban)

Prescription medicineOnly Available By Prescription
Sezzle

Top brand choice

Strength Pack Size Qty
Strength
2.5mg
Pack Size
Qty
Strength
10mg
Pack Size
Qty
Strength
15mg
Pack Size
Qty
Strength
20mg
Pack Size
Qty

You'll have option to make 4 interest-free payments by credit card once your order is confirmed using

Top Generic choice

Strength Pack Size Qty
Strength
2.5mg
Pack Size
Qty
Strength
10mg
Pack Size
Qty
Strength
15mg
Pack Size
Qty
Strength
20mg
Pack Size
Qty

You'll have option to make 4 interest-free payments by credit card once your order is confirmed using

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

XARELTO (Rivaroxaban) is a medication used to treat or prevent the development of clots in certain patients. It can be prescribed for the following conditions:

  • Prevention of clot-related major cardiovascular events in people with Coronary Artery Disease (CAD) or Peripheral Artery Disease (PAD)
  • Prevention of the formation of clots in people with Non-valvular Atrial Fibrillation
  • Prevention of the recurrence of Deep Vein Thrombosis (DVT) or Pulmonary Embolism (PE)
  • Prophylaxis of clot formation in people hospitalized for an acute medical condition and are at a high risk of Venous Thromboembolism
  • Prophylaxis of Deep Vein Thrombosis (DVT) following hip or knee replacement surgery
  • Treatment of active Deep Vein Thrombosis (DVT)
  • Treatment of Pulmonary Embolism (PE)

XARELTO works by inhibiting factor Xa (Ten A), which is a critical protein in the clotting cascade. Inhibition of factor Xa decreases the risk of clot formation (Venous Thromboembolism or Deep Vein Thrombosis). Clots can break off and cause major ischemic events like a cardiovascular accident (stroke), myocardial infarction (heart attack), and pulmonary embolism. Prevention of clot formation has been shown to reduce the risk of these events.

You may take XARELTO for any length of time between three months to lifelong, depending on your clot risk and the determination by the physician.


Fact Table

Formula

C19H18ClN3O5S

License

US FDA, EU EMA, US DailyMed

Bioavailability

80–100%

Legal status

Rx-Only

Chemical Name

Rivaroxaban

Elimination half-life

5–9 hours

Dosage (Strength)

2.5mg, 10mg, 15mg, 20mg

Pregnancy

Consult Doctor

Brands

Xarelto

Protein binding

92% to 95%

PubChem CID

6433119

MedlinePlus

a611049

ChEBI

68579

ATC code

B01AF01

DrugBank

DB06228

KEGG

D07086

Routes of administration

By mouth

Directions

The dosage of XARELTO depends on why you are taking it:

  • Non-valvular Atrial Fibrillation: Take 20 mg once daily with food.
  • DVT or PE treatment: Take 15 mg twice daily with food for 21 days, and then take 20 mg once daily with food.
  • DVT or PE recurrence prevention: Take 10 mg once daily with or without food following 6 months of standard anticoagulation treatment.
  • Prophylaxis for major cardiovascular events in CAD or PAD: Take 2.5 mg twice daily with or without food along with aspirin.

Doses of XARELTO greater than 10 mg should be taken with food to ensure full absorption of the drug.

If you have mild to moderate renal impairment, your physician may prescribe a reduced dose of XARELTO. It should not be taken by those with severe renal impairment.

Ingredients

The active ingredient in XARELTO is Rivaroxaban.

Cautions

Speak with your physician before discontinuing XARELTO, as doing so may temporarily increase the risk of clot formation.

The risk of fatal and non-fatal bleeding events is increased while taking XARELTO, which should be weighed against the risk of clotting events. XARELTO should be used with caution with other drugs that impair hemostasis like NSAIDs, SSRIs, SNRIs, antiplatelets, antifibrinolytics, and other antithrombotics.

The dosage of XARELTO will need to be adjusted in people with renal impairment. The drug should be avoided in those with hepatic impairment.

XARELTO and other factor Xa inhibitors have not been established as safe and effective in patients at an increased clot risk due to heart valve replacements or in those with triple-positive antiphospholipid antibody syndrome.

Side Effects

Since XARELTO is intended to prolong the amount of time it takes blood to clot, the most common side effects will be related to bleeding, and may include:

  • A decrease in hemoglobin caused by bleeding
  • Bruising
  • Fatal bleeding
  • Gastrointestinal bleed
  • Hemorrhagic stroke
  • Intracranial hemorrhage (ICH)
  • Non-major bleeding

Other non-bleeding-related side effects include:

  • Abdominal pain
  • Anxiety
  • Back pain
  • Blister
  • Depression
  • Dizziness
  • Fatigue
  • Insomnia
  • Muscle spasm
  • Pruritis
  • Syncope

References

  1. DailyMed “Xarelto package insert.” Published 2019. Accessed November 15, 2019.
  2. Kearon C, Akl EA, Ornelas J, et al. “Antithrombotic Therapy for VTE Disease.” Chest. 2016;149(2):315-352. doi:10.1016/j.chest.2015.11.026

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

product-reviews Product Reviews