Xarelto (Rivaroxaban)

Prescription medicineOnly Available By Prescription

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We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

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  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
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  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


XARELTO (Rivaroxaban) is a medication used to treat or prevent the development of clots in certain patients. It can be prescribed for the following conditions:

  • Prevention of clot-related major cardiovascular events in people with Coronary Artery Disease (CAD) or Peripheral Artery Disease (PAD)
  • Prevention of the formation of clots in people with Non-valvular Atrial Fibrillation
  • Prevention of the recurrence of Deep Vein Thrombosis (DVT) or Pulmonary Embolism (PE)
  • Prophylaxis of clot formation in people hospitalized for an acute medical condition and are at a high risk of Venous Thromboembolism
  • Prophylaxis of Deep Vein Thrombosis (DVT) following hip or knee replacement surgery
  • Treatment of active Deep Vein Thrombosis (DVT)
  • Treatment of Pulmonary Embolism (PE)

XARELTO works by inhibiting factor Xa (Ten A), which is a critical protein in the clotting cascade. Inhibition of factor Xa decreases the risk of clot formation (Venous Thromboembolism or Deep Vein Thrombosis). Clots can break off and cause major ischemic events like a cardiovascular accident (stroke), myocardial infarction (heart attack), and pulmonary embolism. Prevention of clot formation has been shown to reduce the risk of these events.

You may take XARELTO for any length of time between three months to lifelong, depending on your clot risk and the determination by the physician.

Fact Table







Legal status


Chemical Name


Elimination half-life

5–9 hours

Dosage (Strength)

2.5mg, 10mg, 15mg, 20mg


Consult Doctor



Protein binding

92% to 95%

PubChem CID






ATC code






Routes of administration

By mouth


The dosage of XARELTO depends on why you are taking it:

  • Non-valvular Atrial Fibrillation: Take 20 mg once daily with food.
  • DVT or PE treatment: Take 15 mg twice daily with food for 21 days, and then take 20 mg once daily with food.
  • DVT or PE recurrence prevention: Take 10 mg once daily with or without food following 6 months of standard anticoagulation treatment.
  • Prophylaxis for major cardiovascular events in CAD or PAD: Take 2.5 mg twice daily with or without food along with aspirin.

Doses of XARELTO greater than 10 mg should be taken with food to ensure full absorption of the drug.

If you have mild to moderate renal impairment, your physician may prescribe a reduced dose of XARELTO. It should not be taken by those with severe renal impairment.


The active ingredient in XARELTO is Rivaroxaban.


Speak with your physician before discontinuing XARELTO, as doing so may temporarily increase the risk of clot formation.

The risk of fatal and non-fatal bleeding events is increased while taking XARELTO, which should be weighed against the risk of clotting events. XARELTO should be used with caution with other drugs that impair hemostasis like NSAIDs, SSRIs, SNRIs, antiplatelets, antifibrinolytics, and other antithrombotics.

The dosage of XARELTO will need to be adjusted in people with renal impairment. The drug should be avoided in those with hepatic impairment.

XARELTO and other factor Xa inhibitors have not been established as safe and effective in patients at an increased clot risk due to heart valve replacements or in those with triple-positive antiphospholipid antibody syndrome.

Side Effects

Since XARELTO is intended to prolong the amount of time it takes blood to clot, the most common side effects will be related to bleeding, and may include:

  • A decrease in hemoglobin caused by bleeding
  • Bruising
  • Fatal bleeding
  • Gastrointestinal bleed
  • Hemorrhagic stroke
  • Intracranial hemorrhage (ICH)
  • Non-major bleeding

Other non-bleeding-related side effects include:

  • Abdominal pain
  • Anxiety
  • Back pain
  • Blister
  • Depression
  • Dizziness
  • Fatigue
  • Insomnia
  • Muscle spasm
  • Pruritis
  • Syncope


  1. DailyMed “Xarelto package insert.” Published 2019. Accessed November 15, 2019.
  2. Kearon C, Akl EA, Ornelas J, et al. “Antithrombotic Therapy for VTE Disease.” Chest. 2016;149(2):315-352. doi:10.1016/j.chest.2015.11.026

Frequently Asked Questions about Xarelto

What is Xarelto used for?

Xarelto is prescribed to adults for various conditions such as preventing strokes in non-valvular atrial fibrillation (NVAF), treating pulmonary embolism (PE) and deep vein thrombosis (DVT), and preventing recurrent PE and DVT.

What are the side effects of Xarelto?

Common side effects of Xarelto include bleeding, anemia, fatigue, dizziness, nausea, and headaches due to its blood-thinning properties.

What is the most common side effect of Xarelto?

The most common side effect of Xarelto is bleeding, which can manifest as nosebleeds, bruising, gum bleeding, or prolonged bleeding from minor cuts or injuries.

What happens if you miss a dose of Xarelto?

If you miss a dose of Xarelto, take it as soon as you remember. If it’s close to the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Avoid doubling up on doses.

Does Xarelto cause muscle pain?

Muscle pain is not a common side effect of Xarelto. Consult your doctor if you experience any unusual symptoms.

Is Xarelto a blood thinner?

Yes, Xarelto is classified as a blood thinner (anticoagulant) to prevent blood clots.

Are there any food restrictions with Xarelto?

Unlike warfarin, Xarelto does not have specific dietary restrictions. However, maintaining a balanced diet and avoiding excessive alcohol consumption is recommended.

What to avoid while taking Xarelto?

While on Xarelto, avoid activities that may cause bleeding or injury, consult your doctor before taking other medications, and avoid grapefruit or grapefruit juice.

Is Xarelto a high risk medication?

Xarelto is considered a high-risk medication due to its potential for bleeding complications. Regular monitoring and adherence to dosing instructions are essential.

How long can you stay on Xarelto?

The duration of Xarelto treatment depends on your medical condition. Consult your doctor for personalized guidance. It's typically prescribed for 1 to 12 months for treating VTE in children.

What is the best time of day to take Xarelto blood thinner?

Take Xarelto at the same time each day, preferably with the evening meal.

Can I drink alcohol while on Xarelto?

Moderate alcohol consumption is generally acceptable while taking Xarelto, but consult your doctor for personalized advice.

Can XARELTO affect your sleep?

There’s no direct evidence that Xarelto affects sleep. Discuss any sleep disturbances with your healthcare provider.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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