Wixela (Fluticasone / Salmeterol)

Description

Wixela (Fluticasone / Salmeterol) is a combination of two medications that help control asthma symptoms and improve breathing. As a corticosteroid and long-acting beta-agonist combination, it provides relief for those with uncontrolled asthma or chronic obstructive pulmonary disease (COPD). This dual-action therapy may help prevent asthma attacks and COPD flare-ups. It comes as an oral inhaler.

Directions

The standard dosage for Wixela varies depending on the condition being treated and the individual's response to therapy. If using Wixela for asthma, be aware that it is not intended for relief of an asthma attack that has already begun. In this case, a separate fast-acting inhaler should be used. If treating asthma or COPD, use Wixela consistently as prescribed by a healthcare professional, even if symptoms improve.

To administer Wixela doses, you can follow these steps:

1. Open the inhaler: Hold the inhaler in your left hand and place your right thumb in the thumb grip. Push the thumb grip away from you until the mouthpiece shows and snaps into place.
2. Slide the lever: Slide the lever until you hear it click. This prepares the medication for inhalation.
3. Inhale the medication: Place the mouthpiece in your mouth and close your lips around it. Breathe in quickly and deeply through your mouth, ensuring that the medication is inhaled.
4. Remove the inhaler: Take the inhaler out of your mouth and hold your breath for about 10 seconds, or as long as you comfortably can, to allow the drug to settle into your lungs.
5. Rinse your mouth: After using the inhaler, rinse your mouth with water without swallowing to help reduce the risk of oropharyngeal candidiasis, a possible side effect of the medication.

Ingredients

Wixela Inhub is a combination of two active ingredients: fluticasone propionate and salmeterol inhalation powder. Fluticasone propionate is a corticosteroid that helps reduce inflammation in the airways, while salmeterol is a long-acting beta-adrenergic agonist (LABA) that works to relax the muscles around the airways, making it easier to breathe.

Contraindications

Avoid taking or using this medication if any of the following apply:

• Severe hypersensitivity to milk proteins
• Demonstrated hypersensitivity to fluticasone propionate, salmeterol, or any of the excipients in Wixela Inhub
• An allergy to any part of Wixela Inhub (fluticasone and salmeterol inhalation powder) or any other drugs, foods, or substances

Cautions

• Before starting Wixela Inhub, inform your doctor about any of the following:
• Any medications you take, including monoamine oxidase inhibitors (MAOIs) or tricyclic antidepressants.
• Medical conditions you have.
• Whether you are pregnant or breastfeeding.
• Do not use Taltz if your asthma or COPD is getting worse, or to treat sudden breathing problems.
• Avoid using Taltz with other medicines that contain long-acting beta-agonists to prevent an overdose.
• There's a chance of getting a yeast infection in the mouth or throat. After using Taltz, rinse your mouth with water but do not swallow, to lower this risk.
• People with COPD may have a higher risk of pneumonia. Watch out for symptoms like cough or fever, and tell your doctor if they occur.
• If you have infections like tuberculosis or herpes, Taltz could make them worse. Be extra careful and check with your doctor if you have any infections.
• Switching from steroid pills to Taltz needs to be done carefully to avoid affecting your adrenal gland.
• High doses, or sometimes even regular doses, can lead to conditions like hypercorticism and adrenal suppression. If you notice unusual symptoms, you may need to stop Taltz gradually.
• If you experience sudden and severe worsening of breathing after using Taltz, stop immediately and seek alternative treatment.
• If you have heart or nervous system conditions, use Taltz with caution because of its stimulating effects.
• Taltz can affect bone strength. Your doctor may check your bone health over time.
• Monitor the growth of children on Taltz, as it can be affected.
• Long-term use can lead to eye problems like glaucoma and cataracts. If you have eye issues, you might need to see an eye doctor.
• Be aware of possible blood problems like low potassium or high blood sugar, especially if you have conditions like eosinophilic disorders or diabetes.

Side Effects

Wixela can cause various side effects in some people. The most common Wixela side effects include headache, sore throat, cough, nausea, hoarseness, and voice changes. There are also more serious side effects associated with Wixela Inhub that may require immediate medical attention. These include pneumonia, sudden breathing problems, adrenal gland problems, heart problems, bone thinning, eye problems, and serious allergic reactions. In addition, fluticasone, one of the components of the drug, can affect growth in children. If you experience any of these severe side effects, seek medical advice as soon as possible.

References:

1. Wixela (Fluticasone / Salmeterol) Product Monograph. Morgantown, WV: Mylan Pharmaceuticals; 2019.
2. Wixela (Fluticasone / Salmeterol) Drug Label Information. Morgantown, WV: Mylan Pharmaceuticals; 2022.

About Dr. Gerardo Sison (Page Author)

An honors graduate of the University of Florida, Dr. Sison started his pharmacy career in a community setting, extending his services to hospitals and clinics over time. He has also worked in medication therapy management, advising patients on proper medication use for their chronic health conditions. Read More....