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Wixela (Fluticasone / Salmeterol)

Prescription medicineOnly Available By Prescription

Top brand choice

Strength Pack Size Qty
100mcg/50mcg (60 doses)
Pack Size
250mcg/50mcg (60 doses)
Pack Size
500mcg/50mcg (60 doses)
Pack Size

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Wixela (Fluticasone / Salmeterol) is a combination of two medications that help control asthma symptoms and improve breathing. As a corticosteroid and long-acting beta-agonist combination, it provides relief for those with uncontrolled asthma or chronic obstructive pulmonary disease (COPD). This dual-action therapy may help prevent asthma attacks and COPD flare-ups. It comes as an oral inhaler.

Fact Table


Fluticasone: C22H27F3O4S Salmeterol: C25H37NO4




Fluticasone: 1%, Salmeterol: about 4%

Legal status


Chemical Name

Fluticasone / Salmeterol

Elimination half-life

5.5 to 7.8 hours

Dosage (Strength)

100mcg / 50mcg (60 doses), 250mcg / 50mcg (60 doses), 500mcg / 50mcg (60 doses)


Consult Doctor



Protein binding

Fluticasone: 99% Salmeterol: 96%

PubChem CID

Fluticasone: 5311101 Salmeterol: 5152




Fluticasone: 31441 Salmeterol: 9014

ATC code



Fluticasone: DB00588 Salmeterol: DB00938


Fluticasone: D07981 Salmeterol: D00687

Routes of administration



The standard dosage for Wixela varies depending on the condition being treated and the individual's response to therapy. If using Wixela for asthma, be aware that it is not intended for relief of an asthma attack that has already begun. In this case, a separate fast-acting inhaler should be used. If treating asthma or COPD, use Wixela consistently as prescribed by a healthcare professional, even if symptoms improve.

To administer Wixela doses, you can follow these steps:

  1. Open the inhaler: Hold the inhaler in your left hand and place your right thumb in the thumb grip. Push the thumb grip away from you until the mouthpiece shows and snaps into place.
  2. Slide the lever: Slide the lever until you hear it click. This prepares the medication for inhalation.
  3. Inhale the medication: Place the mouthpiece in your mouth and close your lips around it. Breathe in quickly and deeply through your mouth, ensuring that the medication is inhaled.
  4. Remove the inhaler: Take the inhaler out of your mouth and hold your breath for about 10 seconds, or as long as you comfortably can, to allow the drug to settle into your lungs.
  5. Rinse your mouth: After using the inhaler, rinse your mouth with water without swallowing to help reduce the risk of oropharyngeal candidiasis, a possible side effect of the medication.


Wixela Inhub is a combination of two active ingredients: fluticasone propionate and salmeterol inhalation powder. Fluticasone propionate is a corticosteroid that helps reduce inflammation in the airways, while salmeterol is a long-acting beta-adrenergic agonist (LABA) that works to relax the muscles around the airways, making it easier to breathe.


Avoid taking or using this medication if any of the following apply:

  • Severe hypersensitivity to milk proteins
  • Demonstrated hypersensitivity to fluticasone propionate, salmeterol, or any of the excipients in Wixela Inhub
  • An allergy to any part of Wixela Inhub (fluticasone and salmeterol inhalation powder) or any other drugs, foods, or substances


  • Before starting Wixela Inhub, inform your doctor about any of the following:
    • Any medications you take, including monoamine oxidase inhibitors (MAOIs) or tricyclic antidepressants.
    • Medical conditions you have.
    • Whether you are pregnant or breastfeeding.
  • Do not use Taltz if your asthma or COPD is getting worse, or to treat sudden breathing problems.
  • Avoid using Taltz with other medicines that contain long-acting beta-agonists to prevent an overdose.
  • There's a chance of getting a yeast infection in the mouth or throat. After using Taltz, rinse your mouth with water but do not swallow, to lower this risk.
  • People with COPD may have a higher risk of pneumonia. Watch out for symptoms like cough or fever, and tell your doctor if they occur.
  • If you have infections like tuberculosis or herpes, Taltz could make them worse. Be extra careful and check with your doctor if you have any infections.
  • Switching from steroid pills to Taltz needs to be done carefully to avoid affecting your adrenal gland.
  • High doses, or sometimes even regular doses, can lead to conditions like hypercorticism and adrenal suppression. If you notice unusual symptoms, you may need to stop Taltz gradually.
  • If you experience sudden and severe worsening of breathing after using Taltz, stop immediately and seek alternative treatment.
  • If you have heart or nervous system conditions, use Taltz with caution because of its stimulating effects.
  • Taltz can affect bone strength. Your doctor may check your bone health over time.
  • Monitor the growth of children on Taltz, as it can be affected.
  • Long-term use can lead to eye problems like glaucoma and cataracts. If you have eye issues, you might need to see an eye doctor.
  • Be aware of possible blood problems like low potassium or high blood sugar, especially if you have conditions like eosinophilic disorders or diabetes.

Side Effects

Wixela can cause various side effects in some people. The most common Wixela side effects include headache, sore throat, cough, nausea, hoarseness, and voice changes. There are also more serious side effects associated with Wixela Inhub that may require immediate medical attention. These include pneumonia, sudden breathing problems, adrenal gland problems, heart problems, bone thinning, eye problems, and serious allergic reactions. In addition, fluticasone, one of the components of the drug, can affect growth in children. If you experience any of these severe side effects, seek medical advice as soon as possible.


  1. Wixela (Fluticasone / Salmeterol) Product Monograph. Morgantown, WV: Mylan Pharmaceuticals; 2019.
  2. Wixela (Fluticasone / Salmeterol) Drug Label Information. Morgantown, WV: Mylan Pharmaceuticals; 2022.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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