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Wakix (Pitolisant)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Wakix is a newly-developed medication for the treatment of excessive-daytime sleepiness in people with narcolepsy. Narcolepsy is a disease where a person is excessively fatigued throughout the day and may fall asleep at inappropriate times.

Wakix works by blocking histamine-3 receptors. Histamine attaches to receptors in the central nervous system (CNS) and increases feelings of sleepiness.


The starting dosage of Wakix is 8.9 mg by mouth once daily. On week 2, it can be increased to 17.9 mg by mouth once daily. If a higher dose is needed, on week three, it may be increased to 35.6 mg by mouth once daily, which is the maximum dosage.


The active ingredient in this medication is pitolisant.


Tell your doctor about all medications you are taking, including:

  • Apalutamide
  • Ajmaline
  • Antihistamines
  • Artemether and Lumefantrine
  • Benzodiazepines
  • Budesonide
  • Bupropion
  • Calcium Channel Blockers
  • Carbamazepine
  • Carbamazepine
  • Corticosteroids
  • Dacomitinib
  • Enzalutamide
  • Etoposide
  • Fluoxetine
  • Fosphenytoin
  • Haloperidol
  • Hormonal Contraceptives
  • Immunosuppressives
  • Levoketoconazole
  • Lumacaftor
  • Lumacaftor-ivacaftor
  • Macrolide antibiotics
  • Mirtazapine
  • Miscellaneous
  • Mitotane
  • Paroxetine
  • Peginterferon Alfa-2b
  • Phenobarbital
  • Phenytoin
  • Primidone
  • Promethazine
  • QT-prolonging Agents
  • Quinidine
  • Rifampin (rifampicin)
  • Statins
  • Steroids
  • Tipranavir


Tell your healthcare provider if you have a history of kidney or liver problems before starting Wakix.The dosage may need to be adjusted.

There are many potential drug-drug interactions with this medication.

Tell your doctor if you have a history of heart problems.

Side Effects

Common drug-drug interactions may include:

  • Abdominal pain
  • Abnormal behavior
  • Abnormal dreams
  • Anaphylaxis
  • Anxiety
  • Bipolar mood disorder
  • Cataplexy
  • Decreased appetite
  • Depressed mood
  • Depression
  • Epilepsy
  • Fatigue
  • Hallucination
  • Headache
  • Hypersensitivity reaction
  • Increased heart rate
  • Insomnia
  • Irritability
  • Lack of emotion
  • Migraine
  • Musculoskeletal pain
  • Nausea
  • Nightmares
  • Prolonged QT interval on ECG
  • Pruritus
  • Skin rash
  • Sleep disorder
  • Sleep disturbance
  • Sleep paralysis
  • Sleep talking
  • Suicidal ideation
  • Suicidal tendencies
  • Tachycardia
  • Upper respiratory tract infection
  • Weight gain
  • Xerostomia


Wakix [package insert]. Plymouth Meeting, PA: Bioprojet Pharma; 2019.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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