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Vyzulta (Latanoprostene Bunod)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


VYZULTA eye drops are a medication used to treat increased intraocular pressure (IOP) in patients with ocular hypertension or open-angle glaucoma. Increased fluid pressure inside the eye occurs when more fluid is produced than is drained. 

Ocular hypertension is a primary risk factor for glaucoma. Left untreated, glaucoma can lead to visual impairment and permanent optic nerve damage.

VYZULTA eye drops work by a dual mechanism. It is metabolized into two active moieties at the site of action: latanoprost and butanediol mononitrate. Latanoprost works by increasing the expression of proteins that degrade collagen, thereby reducing outflow resistance and producing subsequent pressure reduction. Butanediol mononitrate further metabolizes to nitric oxide, which causes changes in contractility and reduced aqueous humor volume.

Fact Table




US DailyMed



Legal status


Chemical Name

Latanoprostene bunod

Elimination half-life

1.8–4.6 hours

Dosage (Strength)



Not Recommended



Protein binding


PubChem CID






ATC code






Routes of admsinistration

Eye drop


Instill one drop into the conjunctival sac of the affected eyes (s) once daily in the evening. VYZULTA eye drops should not be administered more than once daily as the subsequent effects may diminish.

Separate the administration from other eye drops by at least 5 minutes. Wait 15 minutes after administration of drops to insert contact lenses.

Do not touch the tip of the eyedropper to the surface of the eye or other nonsterile surfaces, as this may contaminate the bottle with bacterial growth.


The active ingredient in VYZULTA eye drops is latanoprostene bunod.

Inactive ingredients include: benzalkonium chloride (preservative), citric acid, EDTA, glycerin, polysorbate 80, sodium citrate, and water.


VYZULTA eye drops can cause permanent pigmentation changes to the iris, and reversible pigmentation changes to the periorbital tissue and eyelashes. Pigmentation changes include a darkening of the affected tissue. Patients prescribed VYZULTA eye drops should be informed of this possibility by their prescribing physician. 

VYZULTA eye drops can increase the length and thickness of eyelashes. These changes are cosmetic and usually reversible upon discontinuation.

Side Effects

The most common adverse effects of VYZULTA eye drops include:

  • Conjunctival hyperemia
  • Eye irritation
  • Eye pain
  • Eyelash changes
  • Instillation site pain
  • Macular edema
  • Pigmentation changes

If you experience any of the above side effects while taking VYZULTA eye drops, let your doctor know. Most side effects will resolve after discontinuing the medication.


  1. DrugBank. "Latanoprostene bunod." Published 2017. Accessed December 11, 2019.
  2. Vyzulta [package insert]. Bridgewater, NJ: Valeant Pharmaceuticals; 2017. Accessed December 11, 2019.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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