Vyzulta (Latanoprostene Bunod)

Prescription medicineOnly Available By Prescription
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Strength Pack Size Qty
Strength
0.024%/5ml
Pack Size
Qty

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We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

VYZULTA eye drops are a medication used to treat increased intraocular pressure (IOP) in patients with ocular hypertension or open-angle glaucoma. Increased fluid pressure inside the eye occurs when more fluid is produced than is drained. 

Ocular hypertension is a primary risk factor for glaucoma. Left untreated, glaucoma can lead to visual impairment and permanent optic nerve damage.

VYZULTA eye drops work by a dual mechanism. It is metabolized into two active moieties at the site of action: latanoprost and butanediol mononitrate. Latanoprost works by increasing the expression of proteins that degrade collagen, thereby reducing outflow resistance and producing subsequent pressure reduction. Butanediol mononitrate further metabolizes to nitric oxide, which causes changes in contractility and reduced aqueous humor volume.


Fact Table

Formula

C27H41NO8

License

US DailyMed

Bioavailability

-

Legal status

Rx-Only

Chemical Name

Latanoprostene bunod

Elimination half-life

1.8–4.6 hours

Dosage (Strength)

0.024%/5ml

Pregnancy

Not Recommended

Brands

Vyzulta

Protein binding

-

PubChem CID

11156438

MedlinePlus

a618001

ChEBI

177703

ATC code

S01EE06

DrugBank

DB11660

KEGG

D10441

Routes of admsinistration

Eye drop

Directions

Instill one drop into the conjunctival sac of the affected eyes (s) once daily in the evening. VYZULTA eye drops should not be administered more than once daily as the subsequent effects may diminish.

Separate the administration from other eye drops by at least 5 minutes. Wait 15 minutes after administration of drops to insert contact lenses.

Do not touch the tip of the eyedropper to the surface of the eye or other nonsterile surfaces, as this may contaminate the bottle with bacterial growth.

Ingredients

The active ingredient in VYZULTA eye drops is latanoprostene bunod.

Inactive ingredients include: benzalkonium chloride (preservative), citric acid, EDTA, glycerin, polysorbate 80, sodium citrate, and water.

Cautions

VYZULTA eye drops can cause permanent pigmentation changes to the iris, and reversible pigmentation changes to the periorbital tissue and eyelashes. Pigmentation changes include a darkening of the affected tissue. Patients prescribed VYZULTA eye drops should be informed of this possibility by their prescribing physician. 

VYZULTA eye drops can increase the length and thickness of eyelashes. These changes are cosmetic and usually reversible upon discontinuation.

Side Effects

The most common adverse effects of VYZULTA eye drops include:

  • Conjunctival hyperemia
  • Eye irritation
  • Eye pain
  • Eyelash changes
  • Instillation site pain
  • Macular edema
  • Pigmentation changes

If you experience any of the above side effects while taking VYZULTA eye drops, let your doctor know. Most side effects will resolve after discontinuing the medication.

References

  1. DrugBank. "Latanoprostene bunod." Drugbank.ca.. Published 2017. Accessed December 11, 2019.
  2. Vyzulta [package insert]. Bridgewater, NJ: Valeant Pharmaceuticals; 2017. Accessed December 11, 2019.

Frequently Asked Questions about Vyzulta


What is Vyzulta used for?

Vyzulta is used to lower eye pressure in people with open-angle glaucoma or ocular hypertension.


What are the side effects of Vyzulta?

Common side effects of Vyzulta include puffy eyelids, mild pain, blurred vision, and feeling like something's in your eye. Less common ones include eye irritation and swelling. Rare side effects include changes in vision, eye pain, and sensitivity to light. Serious side effects may include severe discomfort, redness, sudden vision changes, or severe pain, which require medical attention.


Why is Vyzulta so expensive?

Vyzulta's cost can vary due to factors like research, production, marketing, and distribution.


Is Vyzulta a beta blocker?

No, Vyzulta is not a beta blocker. It works differently by targeting two pathways to reduce eye pressure.


Does Vyzulta need to be refrigerated?

No, Vyzulta should be stored at room temperature, between 15°C and 25°C (59°F and 77°F). Avoid freezing or refrigerating it.


How much does Vyzulta lower eye pressure?

Vyzulta helps lower eye pressure by about 7.5 to 9.1 mmHg on average in studies, for people with an initial eye pressure of around 26.7 mmHg.


Is Vyzulta the same as latanoprost?

Vyzulta contains a modified form of latanoprost called latanoprostene bunod. Both lower eye pressure, but Vyzulta has a dual mechanism of action.


How long can you use Vyzulta?

The duration of Vyzulta use varies depending on your condition and your doctor’s advice. Regular check-ups with an eye specialist are important.


Who should not use Vyzulta?

Vyzulta should not be used by people allergic to it, as it can cause serious reactions. Those with certain eye issues, like swelling, infections, or past surgeries, should inform their doctor. It's not clear if it's safe during pregnancy or breastfeeding, so consult a doctor if you're in that situation. It's not suitable for anyone under 16. Also, it might gradually change eye color or eyelids and lashes, usually making them more brown, and this change could persist even after stopping treatment.



IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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