Voxzogo (Vosoritide)

Prescription medicineOnly Available By Prescription

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Voxzogo (vosoritide) is a C-type natriuretic peptide (CNP) analog indicated to increase linear growth in children with achondroplasia who have open epiphyses (growth plates). Achondroplasia is the most common form of dwarfism caused by a mutation in the FGFR3 gene, which negatively regulates bone growth. Voxzogo works by directly targeting this pathway to promote endochondral ossification and bone elongation, thereby improving height velocity. It is the first and only approved therapy that addresses the underlying pathophysiology of achondroplasia.

Fact Table

Formula

C165H263N51O55S1

License

US FDA (2021)

Bioavailability

Subcutaneous: ~65%

Legal status

Prescription only

Chemical Name

Vosoritide

Elimination half-life

24 minutes

Dosage (Strength)

0.4 mg, 0.56 mg, 1.2 mg lyophilized powder for injection

Pregnancy

Not recommended – no adequate data

Brands

Voxzogo

Protein binding

Low (peptide hormone)

PubChem CID

121331120

MedlinePlus

a622056

ChEBI

Not assigned

ATC code

H01AX10

DrugBank

DB14761

KEGG

D12297

Routes of administration

Subcutaneous injection

Directions

Voxzogo is administered by subcutaneous injection once daily.

  • The recommended dose is 15 mcg/kg of body weight once daily.
  • Dosage should be recalculated with changes in weight and adjusted accordingly.

Injection sites (abdomen, thighs, upper arms) should be rotated to reduce risk of local reactions. Voxzogo should be administered at the same time each day, preferably in the evening. Treatment should be initiated and monitored by a healthcare provider experienced in managing pediatric growth disorders.

Ingredients

Active ingredient: vosoritide Inactive ingredients: mannitol, L-histidine, polysorbate 20, and hydrochloric acid (for pH adjustment). Reconstitution with sterile water for injection is required before administration.

Contraindications

Voxzogo is contraindicated in patients with:

  • Hypersensitivity to vosoritide or any component of the formulation
  • Closed epiphyses, as the drug is ineffective once growth plates have fused

Cautions

Voxzogo may cause transient decreases in blood pressure; patients should be monitored for hypotension, particularly within 4 hours after injection. It is not indicated for other forms of short stature not related to achondroplasia. Epiphyseal status must be confirmed via radiologic assessment before initiating therapy. Use in combination with other growth-promoting treatments (e.g., growth hormone) has not been studied and is not recommended. Safety and effectiveness in patients under 6 months of age have not been established.

Side Effects

Common side effects may include:

  • Injection site reactions (pain, erythema, swelling)
  • Vomiting
  • Arthralgia
  • Decreased blood pressure
  • Headache
  • Nausea

Most adverse effects are mild to moderate in severity and self-limiting.

IMPORTANT NOTE: The information provided above is for general awareness and educational purposes only. It is not intended to diagnose, treat, or replace professional medical or veterinary advice. Always consult your physician, pharmacist, or veterinarian regarding the safety, suitability, and proper use of any medication for yourself or your pet.

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