Vivelle Dot (Estradiol)

Also Known as Estradot

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Chemical Name: ESTRADIOL (es-tra-DYE-ol)

VIVELLE DOT is a female hormone usually given to women who no longer are able to produce the proper amount of hormones such as estrogen. It can help control moderate to severe symptoms of menopause, including hot flashes, night sweats, vaginal dryness and atrophy. VIVELLE DOT also helps reduce the risk of postmenopausal osteoporosis, which is a major health concern for women after menopause.

The generic Vivelle Dot patches are larger and oval in shape.

Fact Table






Transdermal (through skin) bioavailability varies; specific data for Vivelle Dot not readily available but generally considered to be efficient due to the bypassing of first-pass metabolism

Legal status

Prescription drug in the U.S. and many other countries

Chemical Name


Elimination half-life

Approximately 13 to 20 hours when administered transdermally

Dosage (Strength)

Transdermal patch: 0.025 mg/day, 0.0375 mg/day, 0.05 mg/day, 0.075 mg/day, 0.1 mg/day


Not recommended during pregnancy. Classified as FDA pregnancy category X.


Vivelle-Dot, among others

Protein binding

Approximately 98%

PubChem CID






ATC code






Routes of administration



The dosage for VIVELLE DOT will be different for each patient. Closely follow the directions on the label. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medication that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.


All estrogen therapies carry risk because they can increase the chances of getting cancer of the uterus (womb). You should report any unusual vaginal bleeding right away while you are taking estrogens. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb).

Do not use estrogens (with or without progestins) to prevent heart disease, heart attacks or strokes. Using estrogens (with or without progestins) may increase your chances of getting heart attacks, strokes, breast cancer, and blood clots. Using estrogens may increase your risk of dementia (decline in memory and thinking skills).

VIVELLE DOT (estrogen therapy) should not be used if you:

  • are allergic to CombiPatch or any of its ingredients
  • have unusual vaginal bleeding
  • currently have or have had certain cancers, including cancer of the breast or uterus
  • had a stroke or heart attack in the recent past (for example, in the past year)
  • currently have or have had blood clots
  • currently have or have had liver problems
  • may be pregnant
To make sure you can safely use VIVELLE DOT, tell your doctor if you have any of these other conditions:
  • high blood pressure, angina, or heart disease
  • high cholesterol
  • liver disease
  • kidney disease
  • asthma
  • epilepsy or other seizure disorder
  • migraines
  • diabetes
  • depression
  • gallbladder disease
  • if you have had your uterus removed (hysterectomy)

Side Effects

All medications may cause side effects, but usually patients have no, or minor, side effects. Common side effects of VIVELLE DOT may include:

  • headaches
  • breast tenderness
  • back pain

Less serious side effects may include:

  • nausea, vomiting, loss of appetite;
  • swollen breasts;
  • acne or skin color changes;
  • decreased sex drive, impotence, or difficulty having an orgasm;
  • migraine headaches or dizziness;
  • vaginal pain, dryness, or discomfort;
  • swelling of your ankles or feet;
  • depression; or
  • changes in your menstrual periods, break-through bleeding

Serious side effects may include:

  • chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling
  • sudden numbness or weakness, especially on one side of the body
  • sudden severe headache, confusion, problems with vision, speech, or balance
  • pain or swelling in your lower leg
  • abnormal vaginal bleeding
  • pain, swelling, or tenderness in your stomach
  • jaundice (yellowing of the skin or eyes)
  • a lump in your breast

Frequently Asked Questions about Vivelle-Dot

What is Vivelle-Dot?

Vivelle-Dot is a skin patch with estrogen to help with menopause symptoms like hot flashes and vaginal dryness. It can also prevent bone issues after menopause and treat ovarian problems.

Why is Vivelle-Dot so expensive?

Vivelle-Dot costs a lot because of research, testing, and being a brand-name drug. Generic versions are cheaper, and there are ways to save money with manufacturer savings cards or coupons.

Can Vivelle-Dot cause weight gain?

Vivelle-Dot doesn't directly cause weight gain, but changes in hormones might affect weight.

Does Vivelle-Dot cause hair loss?

Hair loss isn't a direct side effect of Vivelle-Dot, but it could be related to hormones or other reasons.

What are the benefits of Vivelle-Dot?

Vivelle-Dot helps with menopause symptoms, prevents bone issues after menopause, and treats ovarian problems.

What is the difference between Climara and Vivelle-Dot?

Both have estrogen, but they might have different doses and how they release it. Ask your doctor for advice.

Is Vivelle-Dot estrogen only?

Yes, Vivelle-Dot has estradiol, which is a type of estrogen.

How long does it take for Vivelle-Dot patch to start working?

Vivelle-Dot starts working as soon as you put it on. It gives a steady dose of estrogen to help with menopause symptoms.

Can you shower with Vivelle-Dot?

Yes, you can shower while wearing Vivelle-Dot. It stays in place during daily activities.

How many patches come in a Vivelle-Dot box?

The number of patches can change depending on the prescription. Ask your doctor or pharmacist for details.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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