Vimovo (Naproxen/Esomeprazole Mag Trihydrate)

Prescription medicineOnly Available By Prescription

Top brand choice

Strength Pack Size Qty
Pack Size
Pack Size

You'll have option to make 4 interest-free payments by credit card once your order is confirmed using

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Vimovo is a prescription drug that contains the active ingredients naproxen and esomeprazole. If you experience pain symptoms caused by osteoarthritis, rheumatoid arthritis, or ankylosing spondylitis, your doctor may prescribe Vimovo to alleviate them.

This medication contains two active ingredients: naproxen, a nonsteroidal anti-inflammatory drug (NSAID), and esomeprazole, a proton pump inhibitor (PPI). Naproxen and other NSAIDs can cause gastrointestinal symptoms, but the PPI helps prevent them.

Fact Table


C14H14O3(Naproxen), C34H36MgN6O6S2(esomeprazole)


US DailyMed


95%(Naproxen), 90%(esomeprazole)

Legal status


Chemical Name


Elimination half-life

13-15 hr (Naproxen), 1.2-1.5 hr (esomeprazole)

Dosage (Strength)

375 / 20mg, 500 / 20mg


Consult Doctor



Protein binding

99% (Naproxen), 97% (esomeprazole)

PubChem CID

156391 (Naproxen), 9568614 (esomeprazole)





ATC code






Routes of administration

By mouth


The two different formulations of Vimovo include:

  • Naproxen-esomeprazole 375 mg/20 mg
  • Naproxen-esomeprazole 500 mg/20 mg

The usual dosage of Vimovo is one tablet by mouth twice daily with food.


The active ingredients in Vimovo are naproxen and esomeprazole.

Naproxen reduces inflammation and pain in the body, while esomeprazole reduces the amount of acid produced in the stomach.


  • ACE inhibitors (e.g., lisinopril, enalapril)
  • Angiotensin II receptor blockers (ARBs) (e.g. losartan, valsartan)
  • Aspirin
  • Beta-blockers (e.g., metoprolol, carvedilol)
  • Chlorthalidone
  • Citalopram
  • Clopidogrel
  • Cyclosporine
  • Digoxin
  • Duloxetine
  • Eliquis
  • Escitalopram
  • Fluoxetine
  • Furosemide
  • Hydrochlorothiazide
  • Lithium
  • Lovenox
  • Methotrexate
  • Methotrexate
  • Methylprednisolone
  • Prednisone
  • Sertraline
  • Tacrolimus
  • Torsemide
  • Venlafaxine
  • Warfarin
  • Xarelto


The risk of side effects to Vimovo is higher in older adults over 65.

Tell your doctor if you have a history of heart problems before starting Vimovo.

Tell your doctor if you have a history of gastrointestinal disease, especially GI bleeding.

Long-term usage of PPI medications can increase the risk of osteoporosis.

Long-term usage of NSAIDs can increase the risk of gastrointestinal disease.

Ask your doctor and pharmacist for a full list of precautions related to you.

Side Effects

  • Abdominal distension
  • Abdominal pain
  • Abnormal gait
  • Acute myocardial infarction
  • Bruise
  • Cerebrovascular accident
  • Constipation
  • Coronary thrombosis
  • Diarrhea
  • Dizziness
  • Dysgeusia
  • Flatulence
  • Gastritis
  • Gastroesophageal reflux disease
  • Gastrointestinal hemorrhage
  • Gastrointestinal inflammation
  • Gastrointestinal perforation
  • Gastrointestinal ulcer
  • Hematochezia
  • Peripheral edema
  • Upper abdominal pain
  • Urinary tract infection


  1. Vimovo [package insert]. Deerfield, IL: AstraZeneca; 2014.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

product-reviews Product Reviews