Vfend (Voriconazole)

Prescription medicineOnly Available By Prescription
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Strength
200mg
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Strength
50mg
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200mg
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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Vfend (voriconazole) is a medication used to treat adults and pediatric patients two years of age or older who have certain fungal infections.


Fact Table

Formula

C16H14F3N5O

License

US DailyMed, EU EMA, US FDA

Bioavailability

96%

Legal status

Rx-only

Chemical Name

Voriconazole

Elimination half-life

Dose-dependent

Dosage (Strength)

50mg

Pregnancy

Not Recommended

Brands

Vfend

Protein binding

58%

PubChem CID

71616

MedlinePlus

a605022

ChEBI

10023

ATC code

J02AC03

DrugBank

DB00582

KEGG

D00578

Routes of administration

By mouth

Directions

Follow the instructions that come with your prescription. If you have any questions or concerns, don't hesitate to reach out to your doctor or pharmacist.

Vfend comes in tablets of 50 mg and 200 mg strengths. It's also available in a 40 mg/mL oral suspension.

Maintenance Dose in Adults Weighing 40 kg or More

200 mg by mouth every 12 hours

Maintenance Dose in Adults Weighing Less Than 40 kg

100 mg or 150 mg by mouth every 12 hours

Maintenance Dose in Pediatric Patients Who are 2 to 11 Years of Age

9 mg per kg by mouth every 12 hours (maximum 350 mg every 12 hours)

Maintenance Dose in Pediatric Patients Who 12 to 14 Years of Age and Weigh Less Than 50 kg

9 mg per kg by mouth every 12 hours (maximum 350 mg every 12 hours)

Maintenance Dose in Pediatric Patients Who are 12 to 14 Years of Age and Weigh 50 kg or More

Use adult dose

Maintenance Dose in Pediatric Patients Who are 15 Years of Age and Older

Use adult dose

The dose may require an adjustment in adults who have liver or kidney issues.

Vfend tablets and oral suspension should be stored at room temperature. Throw away the suspension after 14 days.

Shake the suspension for about 10 seconds before each use. Use the dropper that comes with your prescription.

Ingredients

The active ingredient in Vfend is voriconazole. 

The inactive ingredients in Vfend tablets include croscarmellose sodium, lactose monohydrate, magnesium stearate, povidone, pregelatinized starch, and a coating containing hypromellose, lactose monohydrate, titanium dioxide, and triacetin.

The inactive ingredients in the Vfend oral suspension include anhydrous citric acid, colloidal silicon dioxide, natural orange flavor, sodium benzoate, sodium citrate dihydrate, sucrose, titanium dioxide, and xanthan gum.

Contraindications

Avoid taking Vfend if you have an allergy to voriconazole or any of the other ingredients or excipients in Vfend.

Avoid taking Vfend with pimozide, quinidine, sirolimus, or ivabradine as drug interactions may occur and lead to serious reactions. If you do not know if you are taking any of these medications, ask your doctor.

Avoid taking Vfend with rifampin, carbamazepine, long-acting barbiturates, efavirenz, ritonavir, rifabutin, ergot alkaloids, and St. John's Wort as this may cause the medication to be less effective. If you do not know if you are taking any of these medications, ask your doctor.

Avoid taking Vfend with naloxegol, tolvaptan, and lurasidone as drug interactions may occur and lead to serious reactions. If you do not know if you are taking any of these medications, ask your doctor.

Avoid taking Vfend with venetoclax at the start of and during the ramp up phase in patients who have chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). Drug interactions may occur and lead to serious reactions. If you do not know if you are taking venetoclax, ask your doctor.

Cautions

  • Before treatment with Vfend is initiated, talk to your doctor:
    • About your allergies
    • About your medical conditions
    • About all the prescription and nonprescription medications you take. These also include vitamins and herbal supplements.
    • About your pregnancy status or plans to become pregnant.
    • About your breastfeeding status or plans to breastfeed.
  • Liver dysfunction or injury can occur with the use of Vfend. Liver function should be checked.
  • Arrhythmias and QT prolongation can occur with the use of Vfend. Talk to your doctor about any risk factors you may have.
  • Vision problems can occur with the use of Vfend. Your vision should be checked if you take Vfend for more than 4 weeks.
  • Severe exfoliative cutaneous reactions can occur with the use of Vfend.
  • Photosensitivity can occur with the use of Vfend. Sunlight exposure should be avoided. Wear protective clothing and apply sunscreen with a high SPF if you go out into the sunlight. 
  • Kidney problems or injury can occur with the use of Vfend. Kidney function should be checked.
  • Adrenal dysfunction can occur with the use of Vfend.
  • Vfend can cause fetal harm.
  • Electrolyte abnormalities can occur with the use of Vfend. 
  • Pancreatitis can occur with the use of Vfend. 
  • Skeletal reactions, including fluorosis and periostitis can occur with the use of Vfend. 
  • Intolerance to galactose can occur with the use of Vfend. Avoid taking Vfend if you have glucose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption.

Side Effects

In adult patients, the most common side effects reported include vision problems, fever, nausea, rash, vomiting, chills, headache, abnormal liver function tests, rapid heart rate, and hallucinations.

In pediatric patients, the most common side effects reported include vision problems, fever, vomiting, nosebleeds, nausea, rash, stomach pain, diarrhea, high blood pressure, low potassium levels in the blood, cough, headache, low platelet levels, abnormal ALT, low blood pressure, peripheral edema, high blood glucose levels, rapid heart rate, shortness of breath, low calcium levels in the blood, low phosphorus levels in the blood, abnormal LFT, mucosal inflammation, eye discomfort in the presence of bright lights, abdominal distention, constipation, dizziness, hallucinations, coughing up blood, low albumin levels, low magnesium levels in the blood, kidney problems, and upper respiratory tract infection.

If side effects develop that continue or worry you, inform your doctor right away.

Reference:

Vfend (voriconazole). New York, NY: Pfizer, Inc.; 2022.



IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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