Vetoryl (Trilostane)

Prescription medicineOnly Available By Prescription

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Strength Pack Size Qty
Strength
10mg
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Strength
30mg
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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Vetoryl is a prescription medicine for dogs used to treat Cushing’s disease, a condition caused by excessive cortisol in the body. Its active ingredient, trilostane, lowers cortisol levels by blocking an enzyme in the adrenal glands. It is given as an oral capsule that’s prescribed and monitored by a veterinarian.

Directions

This medication is given to dogs based on their weight, with a starting dose of 1–3 mg per pound of body weight once daily. Veterinarians typically begin with the lowest effective dose and adjust as needed. Most dogs receive their full dose once a day with food, but if symptoms return before the next dose, the daily amount may be divided into two smaller doses given 12 hours apart. In these cases, the larger portion is usually given in the morning. Capsules must be swallowed whole and should never be broken or emptied.

Ingredients

Trilostane is the active ingredient in this drug.

Contraindications

Avoid giving this medication if any of the following apply:

  • Known allergy or hypersensitivity to trilostane
  • Current primary liver disease or kidney insufficiency
  • Pregnancy

Cautions

  • Before giving this medication, you may want to consult a veterinarian about the following:
    • Any existing health conditions
    • Any allergies
    • A list of all medications currently being taken
  • Vetoryl is for dogs only. Keep it out of reach of children, and do not open or split the capsules. Pregnant women should not handle the medication, as accidental exposure may harm an unborn baby.
  • This drug lowers adrenal function, which can sometimes lead to dangerously low hormone levels (hypoadrenocorticism). Some dogs may recover once treatment is stopped, but others may not regain full adrenal function.
  • Your veterinarian will run tests before and during treatment to monitor safety. Stop Vetoryl and contact the veterinarian immediately if your dog develops vomiting, diarrhea, loss of appetite, weight loss, or lethargy.
  • Overdose can be serious and may require fluids, steroids, and hospital care.
  • Vetoryl should not be used at the same time as certain other medications, such as potassium-sparing diuretics or ACE inhibitors, since these can increase the risk of dangerous electrolyte imbalances.
  • Dogs previously treated with mitotane may need extra monitoring before starting Vetoryl, as they can be more sensitive to its effects.
  • Vetoryl does not shrink adrenal tumors. Surgery may be an option for some dogs with adrenal tumors instead of, or in addition to, medication.
  • The safety of Vetoryl has not been evaluated in breeding dogs or lactating females.

Side Effects

The most common side effects of Vetoryl in dogs include reduced appetite, vomiting, diarrhea, weakness, and lethargy. Some dogs may also develop urinary tract infections, joint or muscle issues, skin problems, or changes in behavior such as shaking or trembling. These reactions may be temporary, but owners should watch their pets closely when starting treatment.

More serious side effects can occur, including adrenal gland damage, hypoadrenocorticism (very low cortisol), hemorrhagic diarrhea, collapse, or sudden death. Serious problems are more likely if a dog develops adrenal crisis or adrenal rupture, but even these can sometimes improve if treatment is stopped and managed promptly. Owners should contact their veterinarian immediately if their dog shows severe weakness, collapse, or ongoing digestive problems.

References:

  1. Vetoryl (Trilostane) Drug Label Information. Overland Park, KS: Dechra Veterinary Products; 2024.
  2. Vetoryl (Trilostane) Package Insert. Quebec, Canada: Dechra Veterinary Products; 2024.


IMPORTANT NOTE: The information provided above is for general awareness and educational purposes only. It is not intended to diagnose, treat, or replace professional medical or veterinary advice. Always consult your physician, pharmacist, or veterinarian regarding the safety, suitability, and proper use of any medication for yourself or your pet.

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