Vastarel MR (Trimetazidine)

Also Known as Vastarel MR

Prescription medicineOnly Available By Prescription
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Strength Pack Size Qty
Strength
35mg
Pack Size
Qty

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Vastarel MR is a prescription medication used to manage angina. Trimetazidine improves myocardial glucose utilization and inhibits fatty acid oxidation, thus optimizing cellular energy metabolism. This mechanism helps protect the heart from ischemia or insufficient blood supply, making it particularly beneficial for individuals with angina pectoris and related conditions.

Fact Table
Formula C14H22N2O3 · 2HCl
License Approved in various countries (not FDA approved)
Bioavailability Approximately 90%
Legal status Prescription only
Chemical Name 1-(2,3,4-Trimethoxybenzyl)piperazine dihydrochloride
Elimination half-life Approximately 6 hours
Dosage (Strength) 35 mg modified-release tablets
Pregnancy Not recommended; consult a healthcare provider
Brands Vastarel MR, Trimetazidine MR
Protein binding Approximately 16%
PubChem CID 144204
MedlinePlus Not available
ChEBI 45949
ATC code C01EB15
DrugBank DB09149
KEGG D07162
Routes of administration Oral

Directions

The usual dosage is 35 mg by mouth twice daily with meals.

Ingredients

The active ingredient in Vastarel MR is trimetazidine.

Interactions

Drug-drug interactions for Vastarel MR are not well known. Based on how this drug works, it is likely to interact with antipsychotics, antihypertensives, and medications for angina. Example include:

  • Amlodipine
  • Aripiprazole
  • Atenolol
  • Clozapine
  • Diltiazem
  • Haloperidol
  • Hydrochlorothiazide
  • Isosorbide dinitrate
  • Isosorbide mononitrate
  • Lisinopril
  • Losartan
  • Metoprolol
  • Nitroglycerin
  • Olanzapine
  • Quetiapine
  • Ranolazine
  • Risperidone
  • Valsartan
  • Verapamil
  • Ziprasidone

Cautions

Vastarel MR has not been approved for use in the United States but has been approved in other countries. The European Medicines Agency (EMA) recommends that it be no longer used for tinnitus, vertigo, or vision disturbances.

The EMA recommends caution when prescribing this drug to people with movement disorders like Parkinson's disease, parkinsonian symptoms, tremors, restless legs syndrome (RLS), and other movement disorders.

Side Effects

The most common side effects are:

  • Abdominal pain
  • Constipation
  • Diarrhea
  • Difficulty sleeping
  • Dizziness
  • Drowsiness
  • Extrapyramidal symptoms (unusual movements, including trembling and shaking of the hands and fingers, twisting movements of the body, shuffling walk, and stiffness of the arms and legs), usually reversible after treatment discontinuation
  • Extra heartbeats
  • Fainting
  • Fall
  • Fast or irregular heartbeats (palpitations)
  • Faster heartbeat
  • Feeling of weakness
  • Feeling sick (nausea)
  • Flushing
  • Headache
  • Hives
  • Indigestion
  • Itching
  • Leukopenia
  • Lightheadedness
  • Liver disease
  • Low blood pressure
  • Malaise (generally feeling unwell)
  • Rash
  • Red skin rash with blistering
  • Swelling of the face, lips, mouth, tongue, or throat, which may cause difficulty in swallowing or breathing
  • Thrombocytopenia
  • Vertigo
  • Vomiting

References

Vastarel MR [package insert]. Giddy, France: Les Laboratories; February 2021.



IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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