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Valdoxan (Agomelatine)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Valdoxan is a prescription antidepressant medication used for depression treatment and frequently prescribed for treating depression with anxiety. This medication was developed with patients having major depressive disorder in mind, but as the first antidepressant with a non-monoaminergic component it has since been identified for major depression patients also having severe anxiety. Valdoxan 25mg works as a MT1 and MT2 melatonergic receptors agonist and its effectiveness as a 5-HT2C antagonist is in the way it re-synchronizes circadian rhythms for depressed patients.


Standard dosage is to take 1 Valdoxan 25mg 1x daily at bedtime. Your doctor's determination may mean a different dosage is recommended and you should always take your medication exactly as indicated in your prescription.

Dosage may be adjusted to 50 mg (2 x 25 mg tablets) taken at bedtime if after 2 weeks agomelatine treatment is producing insufficient results.


The active ingredient in Valdoxan is Agomelatine.


Inform your doctor of any history of liver disease, hepatic failure, or general poor liver health / function before starting on Valdoxan. Also inform your doctor of any history of suicidal thoughts or prior suicide attempts before moving forward with using this medication.

Use of this medication may not be suitable for patients over 75 years of age.

Always take medication as consistently as indicated in your prescription. Failing to take medication for any more than a day or two may detract from the medication's effectiveness for depression treatment and less improvement with mood / energy and focus.

In the event of a forgotten dose, do not take a make-up dose. If you forget to take your medication, begin taking it at the same time the next day instead. You should also not take 2 tablets at one time to make up for missing a day's dose.

Do not stop taking Valdoxan medication unless you have discussed with your doctor and they have approved you to stop taking it.


Negative drug interactions are possible between Valdoxan and other Rx medications, including fluvoxamine and ciprofloxacin, a very common antibiotic medication. Inform your doctor of all medications you are currently taking before getting a prescription and proceeding to buy Valdoxan online.

Side Effects

Valdoxan side effects are uncommon, but some users may experience anxiety, back pain, constipation, diarrhea, dizziness, drowsiness, excessive sweating, fatigue, insomnia, migraines and headaches, or nausea. If side effects from Valdoxan are seen it may be best to stop use and speak with your doctor again regarding depression with anxiety treatment medication options.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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