Also Known as Ledaga
Only Available By Prescription
Sign up to get notified if we do in the future.
We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!
Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.
To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.
Terms & Conditions of Program
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Valchlor (mechlorethamine) is a topical antineoplastic gel indicated for the treatment of stage IA and IB mycosis fungoides-type cutaneous T-cell lymphoma (CTCL) in patients who have received prior skin-directed therapy. Mechlorethamine is a nitrogen mustard alkylating agent that works by forming cross-links in DNA, ultimately disrupting replication and leading to apoptosis of malignant T-cells in the skin. Valchlor offers a non-invasive treatment option that targets localized lesions with minimal systemic absorption.
| Fact Table | |
| Formula | C5H11Cl2N |
| License | US FDA (topical: 2013) |
| Bioavailability | Minimal (topical application) |
| Legal status | Prescription only |
| Chemical Name | Mechlorethamine |
| Elimination half-life | Minutes (very short, highly reactive) |
| Dosage (Strength) | 0.016% topical gel (0.16 mg/g) |
| Pregnancy | Contraindicated – may cause fetal harm |
| Brands | Valchlor |
| Protein binding | Reacts covalently; not protein-bound in classical sense |
| PubChem CID | 4033 |
| MedlinePlus | a682221 |
| ChEBI | 51145 |
| ATC code | L01AA05 |
| DrugBank | DB00888 |
| KEGG | D08242 |
| Routes of administration | Topical (gel) |
Valchlor is applied topically once daily to affected areas of the skin. The 0.016% gel should be applied as a thin film to completely dry skin at least 30 minutes after bathing or showering. Hands should be washed immediately after application unless treating the hands themselves, and patients should allow the gel to dry completely before covering the area with clothing. Occlusive dressings should not be used unless directed by a healthcare provider. Avoid application to mucous membranes or broken skin. Treatment should be continued as prescribed, with regular monitoring by a healthcare professional for skin reactions or disease progression.
Each gram of Valchlor contains:
Mechlorethamine hydrochloride 0.016% (equivalent to 0.014% mechlorethamine free base)
Inactive ingredients include:
Diethylene glycol monoethyl ether, propylene glycol, hydroxypropylcellulose, and purified water
Valchlor is supplied in a multi-use aluminum tube with a plastic screw cap and should be stored in the refrigerator (2°C to 8°C). Do not freeze.
Valchlor is contraindicated in patients with:
Hypersensitivity to mechlorethamine or any component of the formulation
Presence of open wounds, ulcerated skin, or active dermatoses where absorption may be increased
Concomitant use with topical products containing silver (e.g., silver sulfadiazine), which can inactivate mechlorethamine
Valchlor is cytotoxic and should be handled with care. Use protective gloves when applying to others. Contact with mucous membranes, eyes, or non-affected skin may cause severe irritation or injury. Patients should avoid sunlight or UV exposure on treated areas due to potential photosensitivity. Secondary malignancies, including skin cancer, have been reported with long-term use of topical nitrogen mustards. Women who are pregnant or breastfeeding should not use Valchlor due to risk of fetal harm. Effective contraception is recommended for both male and female patients during and after treatment.
Common and potential side effects include:
Dermatitis (irritant or allergic)
Pruritus or burning sensation at the application site
Skin ulceration or blisters
Hyperpigmentation or hypopigmentation
Secondary skin infections
Rare: non-melanoma skin cancer, delayed hypersensitivity reactions
Exceptional Customer Service
We pride ourselves on delivering excellent customer service with as much accessibility as possible.
If you have any questions at all, or would like to place an order, you are encouraged to contact us by toll-free
phone 1-888-904-8467 or email info@canadadrugsdirect.com.
Top Safety and Quality
Canada Drugs Direct employs dedicated, professional licensed pharmacists to ensure that each and every order is reviewed before it is dispensed for the safety and health of our customers. At CanadaDrugsDirect.com, your health is our top priority.
Product Reviews