Canada Drugs Direct

Visiting from Canada?

Want to save up to 80% on your medications? Signup below to be notified if we open a Canadian Online Pharmacy.

I agree to receive email updates from Canada Drugs Direct

Looking for Call us toll free 1-800-500-2897

Vagifem (Estradiol)

Prescription medicineOnly Available By Prescription

Top brand choice

Strength Pack Size Qty
Pack Size

You'll have option to make 4 interest-free payments by credit card once your order is confirmed using

Top Generic choice

Strength Pack Size Qty
Pack Size

You'll have option to make 4 interest-free payments by credit card once your order is confirmed using

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Vagifem is a prescription medication used to treat atrophic vaginitis in women who have gone through menopause. After menopause, the natural levels of estrogen decrease because a woman's body is no longer producing as much.

Vagifem works by replacing estrogen in the vagina without absorbing into the bloodstream and causing other side effects. Replacing low estrogen levels helps to treat atrophic vaginitis by increasing the amount of naturally produced lubrication. 


Use the included applicator to insert Vagifem tablets.

The usual dose is one 10-25 mcg tablet once daily for seven days, followed by twice weekly after that.

Store Vagifem at room temperature and not in the refrigerator or freezer.


The active ingredient in Vagifem generic is Estradiol.


Vagifem is unlikely to interact with other medications because it doesn't absorb into the bloodstream. However, you should tell your doctor if you take any of the following:

  • Anastrozole
  • Anticoagulants
  • Apalutamide
  • Carbamazepine
  • Enzalutamide
  • Exemestane
  • Fosphenytoin
  • Growth hormone analogs
  • Mitotane
  • Ospemifene
  • Phenobarbital
  • Phenytoin
  • Pomalidomide
  • Primidone
  • Tipranavir
  • Tizanidine


Keep Vagimen out of reach of children.

You should not use Vagifem if you have any of the following:

  • Active clotting disorder
  • Known or suspected history of breast cancer
  • Known or suspected pregnancy
  • Liver problems
  • Undiagnosed genital bleeding

Talk to your doctor or pharmacy for the complete list of precautions that apply to you.

Side Effects

Vagifem side effects may include:

  • Abdominal pain
  • Arthralgia
  • Arthritis
  • Back pain
  • Bacterial vaginosis
  • Diarrhea
  • Flu-like symptoms
  • Genital candidiasis
  • Headache
  • Hot flash
  • Hypersensitivity reaction
  • Insomnia
  • Leukorrhea
  • Mastalgia
  • Migraine
  • Nausea
  • Pharyngitis
  • Sinusitis
  • Skeletal pain
  • Stress
  • Upper respiratory tract infection
  • Urinary tract infection
  • Urticaria
  • Vaginal discomfort
  • Vaginal hemorrhage
  • Vaginal pain
  • Vaginitis
  • Vulvovaginal pruritus


Vagifem [package insert]. Princeton, NJ: Novo Nordisk; 2009.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

product-reviews Product Reviews