Vabysmo (Faricimab)

Prescription medicineOnly Available By Prescription

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Vabysmo (faricimab-svoa) is a bispecific monoclonal antibody indicated for the treatment of neovascular (wet) age-related macular degeneration (nAMD) and diabetic macular edema (DME). It uniquely targets and inhibits both vascular endothelial growth factor-A (VEGF-A) and angiopoietin-2 (Ang-2), two key pathways involved in retinal vascular leakage, inflammation, and neovascularization. By simultaneously blocking VEGF-A and Ang-2, Vabysmo helps to improve and maintain vision, reduce macular edema, and extend treatment intervals compared to anti-VEGF monotherapy.

Fact Table

Formula

C6544H10014N1734O2030S46

License

US FDA (2022)

Bioavailability

Intravitreal – local ocular effect

Legal status

Prescription only

Chemical Name

Faricimab

Elimination half-life

~7.5 days (ocular)

Dosage (Strength)

6 mg/0.05 mL solution for intravitreal injection

Pregnancy

Category C – Risk not ruled out

Brands

Vabysmo

Protein binding

High (IgG1-based monoclonal antibody)

PubChem CID

162201054

MedlinePlus

a622065

ChEBI

Not assigned

ATC code

S01LA08

DrugBank

DB16608

KEGG

D12349

Routes of administration

Intravitreal injection

Directions

Vabysmo is administered by intravitreal injection under sterile conditions by an ophthalmologist.

  • Neovascular AMD: Initiate with 6 mg every 4 weeks for the first 4 doses, then adjust to every 8, 12, or 16 weeks based on disease activity.
  • Diabetic Macular Edema: Initiate with 6 mg every 4 weeks for at least 4 doses, then adjust to every 4, 8, 12, or 16 weeks depending on individual response.

Each vial is for single-use only. Treatment schedules should be guided by visual acuity and retinal anatomical outcomes as assessed by clinical imaging.

Ingredients

Active ingredient: faricimab-svoa (6 mg/0.05 mL) Inactive ingredients: L-histidine, L-histidine hydrochloride monohydrate, polysorbate 20, and sucrose in water for injection. The solution is preservative-free and should be refrigerated.

Contraindications

Vabysmo is contraindicated in patients with:

  • Ocular or periocular infections
  • Active intraocular inflammation
  • Known hypersensitivity to faricimab or any of the excipients

Cautions

Patients should be monitored for endophthalmitis, retinal detachment, and increased intraocular pressure following injection. Use with caution in patients with a history of stroke, arterial thromboembolic events, or other cardiovascular risks, as systemic VEGF inhibition may contribute to thromboembolic complications. Repeated intraocular injections carry a risk of ocular complications; proper aseptic technique is essential.

Side Effects

Common side effects may include:

  • Conjunctival hemorrhage
  • Vitreous floaters
  • Eye pain
  • Increased intraocular pressure
  • Retinal pigment epithelial detachment

Less common but serious side effects include:

  • Endophthalmitis
  • Retinal detachment
  • Arterial thromboembolic events

IMPORTANT NOTE: The information provided above is for general awareness and educational purposes only. It is not intended to diagnose, treat, or replace professional medical or veterinary advice. Always consult your physician, pharmacist, or veterinarian regarding the safety, suitability, and proper use of any medication for yourself or your pet.

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