Only Available By Prescription
Top Generic choice
| Strength | Pack Size | Qty | |
|---|---|---|---|
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Strength
10mg
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We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!
Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.
To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.
Terms & Conditions of Program
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Uvadex (methoxsalen) is a photoactive psoralen derivative used in conjunction with extracorporeal photopheresis (ECP) for the palliative treatment of the skin manifestations of cutaneous T-cell lymphoma (CTCL) in patients who are unresponsive to other forms of treatment. Methoxsalen intercalates into DNA and, upon activation with ultraviolet A (UVA) light, forms covalent cross-links that inhibit DNA synthesis and cell division, inducing apoptosis in pathogenic T lymphocytes. Uvadex is administered ex vivo as part of a leukapheresis and UVA irradiation procedure, not as a systemic or topical agent.
| Fact Table | |
| Formula | C12H8O4 |
| License | US FDA (approved 1999) |
| Bioavailability | Not applicable (Uvadex is administered extracorporeally) |
| Legal status | Prescription only |
| Chemical Name | 9-Methoxy-7H-furo[3,2-g][1]benzopyran-7-one |
| Elimination half-life | ~0.5 to 1.5 hours (oral); varies with route |
| Dosage (Strength) | 10 mcg/mL sterile solution (used in extracorporeal photopheresis) |
| Pregnancy | Category C – risk cannot be ruled out |
| Brands | Uvadex, Oxsoralen (oral methoxsalen) |
| Protein binding | ~75% |
| PubChem CID | 4116 |
| MedlinePlus | a682299 |
| ChEBI | CHEBI:6827 |
| ATC code | D05AD02 |
| DrugBank | DB00553 |
| KEGG | D08213 |
| Routes of administration | Extracorporeal (via photopheresis), oral (other formulations) |
Uvadex is used only in specialized ECP systems (e.g., Therakos CELLEX):
Do not inject Uvadex directly into the patient. It is for ex vivo use only under direct supervision by trained clinicians in photopheresis units.
Each 10 mL vial of Uvadex contains:
Inactive ingredients:
Uvadex is contraindicated in patients with:
Uvadex is not for oral or direct IV administration. Patients undergoing treatment must wear UVA-blocking eye protection during daylight hours for 24 hours post-treatment to prevent ocular damage. Long-term use is associated with increased risk of skin aging and skin cancers, particularly squamous cell carcinoma. Monitor for photosensitivity reactions, skin changes, and cataract formation. Use with caution in patients with cardiovascular disease or those who have had prior extensive PUVA exposure. Avoid use during pregnancy unless clearly indicated.
Potential side effects may include:
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phone 1-888-904-8467 or email info@canadadrugsdirect.com.
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