Tyzeka (Telbivudine)

Prescription medicineOnly Available By Prescription

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Tyzeka is a drug used for the treatment of hepatitis B infection. Hepatitis B is a virus that infects liver cells. Symptoms of hepatitis B can include abdominal pain, yellowing of the eyes and skin, and dark urine. Many people do not experience any symptoms at all.

Tyzeka works by entering the DNA of hepatitis B cells and preventing their replication. By preventing viral replication, Tyzeka slows the progression of the disease.

Hepatitis B infection is usually chronic and can affect a person for many years. Tyzeka and other antiviral medications are used to suppress the infection and allow a person to live relatively symptom-free.

Fact Table







Legal status


Chemical Name


Elimination half-life

40 to 49 hours

Dosage (Strength)



No Known Risk


Tyzeka, Sebivo

Protein binding


PubChem CID






ATC code






Routes of administration

By mouth


The usual dosage for adults aged 16 and older is 600 mg by mouth once daily. The dosage may need to be adjusted for people with impaired kidney function.


The active ingredient in this drug is telbivudine.


There are only a few drug-drug interactions with Tyzeka, and they include:

  • Cladribine
  • Interferons
  • Peginterferon Alfa-2a


While taking this drug, you may be at an increased risk of peripheral neuropathy, which is pain and tingling in the feet and hands.

Do not stop taking this drug without speaking to your healthcare team.

Tell your doctor if you have a history of lactic acidosis.

Tyzeka may increase the risk of myopathy in certain patients.

Side Effects

The common adverse effects of this drug can include:

  • Abdominal distension
  • Abdominal pain
  • Arthralgia
  • Back pain
  • Cough
  • Diarrhea
  • Dizziness
  • Dyspepsia
  • Exacerbation of hepatitis B
  • Fatigue 
  • Fever
  • Headache
  • Hepatomegaly
  • Hyperbilirubinemia
  • Hypoesthesia
  • Increased amylase
  • Increased creatine phosphokinase
  • Increased serum ALT
  • Increased serum AST 
  • Increased serum lipase
  • Insomnia
  • Lactic acidosis
  • Liver steatosis
  • Myalgia
  • Myopathy
  • Myositis
  • Nausea
  • Neutropenia
  • Paresthesia
  • Peripheral neuropathy
  • Pharyngolaryngeal pain
  • Pruritus
  • Rhabdomyolysis
  • Skin rash
  • Thrombocytopenia


Telbivudine [package insert]. East Hanover, NJ: Novartis Pharmaceuticals Corp; 2013.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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