Tymlos (Abaloparatide)

Prescription medicineOnly Available By Prescription

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Tymlos (abaloparatide) is a human parathyroid hormone–related peptide [PTHrP(1-34)] analog indicated for the treatment of postmenopausal women with osteoporosis at high risk for fracture. It is also approved to increase bone density in men with osteoporosis at high risk for fracture. Abaloparatide activates the parathyroid hormone 1 receptor (PTH1R), stimulating osteoblastic activity and increasing bone formation. Clinical trials have demonstrated significant reductions in the risk of vertebral and nonvertebral fractures with Tymlos use.

Fact Table

Formula

C174H300N56O49

License

US FDA (2017)

Bioavailability

36% (subcutaneous)

Legal status

Prescription only

Chemical Name

Abaloparatide

Elimination half-life

~1 hour

Dosage (Strength)

80 mcg/0.4 mL solution in a prefilled pen

Pregnancy

Not recommended – potential risk to fetus

Brands

Tymlos

Protein binding

Not extensively protein bound

PubChem CID

25070907

MedlinePlus

a617007

ChEBI

146324

ATC code

H05AA05

DrugBank

DB13928

KEGG

D10985

Routes of administration

Subcutaneous injection

Directions

Tymlos is administered by subcutaneous injection in the periumbilical region of the abdomen.

  • Recommended dose: 80 mcg once daily
  • Administer at the same time each day, with or without food
  • Patients should be trained on self-injection technique prior to initiating treatment
  • The treatment duration is limited to 2 years over a lifetime, due to a potential risk of osteosarcoma

Supplementation with calcium and vitamin D is advised as needed to maintain adequate levels during therapy.

Ingredients

Active ingredient: abaloparatide (80 mcg/40 mcL) Inactive ingredients: phenol, acetic acid, sodium acetate trihydrate, and water for injection

Each 3 mL prefilled pen delivers 30 doses and should be stored refrigerated prior to first use; once in use, it may be kept at room temperature for up to 30 days.

Contraindications

Tymlos is contraindicated in patients with:

  • Known hypersensitivity to abaloparatide or any excipients
  • Hypercalcemia
  • Metabolic bone diseases other than osteoporosis
  • Bone metastases or history of skeletal malignancies
  • Paget’s disease
  • Unexplained elevations of alkaline phosphatase
  • Prior external beam or implant radiation therapy involving the skeleton

Cautions

Tymlos may cause transient hypercalcemia; serum calcium should be monitored, especially when used alongside calcium supplements. Use with caution in patients with renal impairment. As with other anabolic bone therapies, Tymlos carries a boxed warning for a potential risk of osteosarcoma based on animal studies—its use is restricted to patients for whom benefits outweigh risks. Orthostatic hypotension has been reported shortly after injection, particularly during the first few doses.

Side Effects

Common side effects may include:

  • Dizziness
  • Nausea
  • Headache
  • Palpitations
  • Fatigue
  • Upper abdominal pain
  • Hypercalciuria
  • Injection site reactions

Serious adverse events may include orthostatic hypotension and potential increased risk of osteosarcoma (observed in animal studies, not confirmed in humans).

IMPORTANT NOTE: The information provided above is for general awareness and educational purposes only. It is not intended to diagnose, treat, or replace professional medical or veterinary advice. Always consult your physician, pharmacist, or veterinarian regarding the safety, suitability, and proper use of any medication for yourself or your pet.

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