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Twynsta (Telmisartan, Amlodipine)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Twynsta is a prescription medication designed to effectively manage high blood pressure. Combining telmisartan and amlodipine as its active components, Twynsta offers a more convenient option for those needing to take multiple medications.

The combination of telmisartan and amlodipine in Twynsta targets high blood pressure through distinct mechanisms. Telmisartan, an angiotensin II receptor blocker, relaxes blood vessels, enhancing blood flow. Amlodipine, a calcium channel blocker, further contributes by easing the heart's workload and dilating blood vessels.


Take Twynsta once or twice daily as directed by your healthcare provider.


The active ingredients are amlodipine and telmisartan.


The most common drug-drug interactions include

  • Alfuzosin
  • Aliskiren
  • ALPRAZolam
  • Amifostine
  • Amphetamines
  • Angiotensin II
  • Angiotensin-Converting Enzyme Inhibitors
  • Antipsychotic Agents
  • Arginine
  • Atosiban
  • Barbiturates
  • Benperidol
  • Brigatinib
  • Brimonidine (Topical)
  • Bromperidol
  • Calcium Salts
  • CarBAMazepine
  • Cardiac Glycosides
  • Charcoal, Activated
  • Clofazimine
  • Clopidogrel
  • CycloSPORINE (Systemic)
  • CYP3A4 Inducers 
  • Dabigatran Etexilate
  • Dantrolene
  • Dapoxetine
  • Dexmethylphenidate
  • Diazoxide
  • Drospirenone-Containing Products
  • DULoxetine
  • Eplerenone
  • Fexinidazole
  • Finerenone
  • Flibanserin
  • Flunarizine
  • Fusidic Acid (Systemic)
  • Heparin
  • Heparins (Low Molecular Weight)
  • Herbal Products with Blood Pressure Effects
  • Hypotension-Associated Agents
  • Indoramin
  • Inhalational Anesthetics
  • Ixabepilone
  • Lemborexant
  • Levodopa-Foslevodopa
  • Lithium
  • Lomitapide
  • Lonafarnib
  • Loop Diuretics
  • Lormetazepam
  • Lovastatin
  • Magnesium Sulfate
  • Melatonin
  • Methylphenidate
  • Midazolam
  • Molsidomine
  • Naftopidil
  • Neuromuscular-Blocking Agents (Nondepolarizing)
  • Nicergoline
  • Nicorandil
  • NiMODipine
  • Nitroprusside
  • Nonsteroidal Anti-Inflammatory Agents
  • Nonsteroidal Anti-Inflammatory Agents (Topical)
  • Obinutuzumab
  • Patiromer
  • Pentoxifylline
  • Pholcodine
  • Phosphodiesterase 5 Inhibitors
  • Pimozide
  • Polyethylene Glycol-Electrolyte Solution
  • Potassium Salts
  • Potassium-Sparing Diuretics
  • Prazosin
  • Prostacyclin Analogues
  • Quinagolide
  • Ramipril
  • Ranolazine
  • Red Yeast Rice
  • Silodosin
  • Simvastatin
  • Sincalide
  • Sirolimus
  • Sodium Phosphates
  • Tacrolimus (Systemic)
  • Terazosin
  • Tolvaptan
  • Triazolam
  • Trimethoprim
  • Ubrogepant


Tell your healthcare team about your heart conditions before starting this drug.

Your potassium levels may increase while taking this drug. Your doctor should monitor potassium levels and kidney function.

Tell your doctor if you experience leg swelling on this medication.

Side Effects

The most common side effects include

  • Back pain
  • Dizziness
  • Edema
  • Hypotension
  • Orthostatic hypotension
  • Peripheral edema (dose-related)
  • Syncope


Twynsta [package insert]. Ridgefield, CT: Boehringer; 2011.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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