Only Available By Prescription
Top brand choice
| Strength | Pack Size | Qty | |
|---|---|---|---|
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Strength
245mg/200mg
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Top Generic choice
| Strength | Pack Size | Qty | |
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Strength
300mg/200mg
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We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!
Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.
To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.
Terms & Conditions of Program
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Truvada is a combination medication containing tenofovir disoproxil fumarate and emtricitabine. They belong to a drug class known as nucleoside reverse transcriptase inhibitors (NRTIs), which work by blocking the action of reverse transcriptase, an enzyme important for the replication of the human immunodeficiency virus (HIV). It is used to help manage HIV infection in adults and children by lowering the amount of virus in the body and supporting the immune system. Truvada is also taken daily as PrEP (pre-exposure prophylaxis) by people at high risk of HIV to help prevent infection, especially when combined with safer sex practices.
| Fact Table | |
| Formula | C22H29O5N6P (Tenofovir) / C8H10FN3O3S (Emtricitabine) |
| License | US FDA, EMA |
| Bioavailability | ~25% (Tenofovir), ~93% (Emtricitabine) |
| Legal status | Rx-only |
| Chemical Name | Tenofovir disoproxil fumarate + Emtricitabine |
| Elimination half-life | Tenofovir: ~17 hours, Emtricitabine: ~10 hours |
| Dosage (Strength) | 300 mg Tenofovir disoproxil fumarate / 200 mg Emtricitabine (1 tablet daily) |
| Pregnancy | Category B – No evidence of risk in humans |
| Brands | Truvada, generic formulations available |
| Protein binding | Tenofovir: <1%; Emtricitabine: ~4% |
| PubChem CID | 6398764 (TDF) / 60877 (Emtricitabine) |
| MedlinePlus | a604030 |
| ChEBI | 68528 (TDF) / 51290 (Emtricitabine) |
| ATC code | J05AR03 |
| DrugBank | DB00300 (TDF) / DB00879 (Emtricitabine) |
| KEGG | D10129 (Truvada combo) |
| Routes of administration | Oral |
Truvada should be taken by mouth once daily at the same time each day, with or without food. For adults and adolescents weighing at least 35 kg, the usual dose is one tablet (containing 200 mg of emtricitabine and 300 mg of tenofovir disoproxil fumarate) daily. For children weighing at least 17 kg, the dose is adjusted by weight. Dosage changes or restrictions may apply if you have impaired kidney function, so follow your healthcare provider’s instructions carefully and avoid missing doses.
Truvada contains the active ingredients emtricitabine and tenofovir disoproxil fumarate.
Do not use this medication for HIV-1 PrEP if you have tested positive for HIV-1 or do not know your HIV-1 status.
Before using Truvada, you may want to consult a healthcare provider about the following:
Any existing health conditions
Any allergies
A list of all medications you are currently taking
Whether you are pregnant or breastfeeding
Before starting Truvada, your doctor should check if you have hepatitis B. If you stop taking Truvada and you do have hepatitis B, the infection can flare up and damage your liver. If that happens, your doctor may recommend starting other hepatitis B treatment.
Truvada is used for PrEP to help lower the risk of getting HIV but only works if you're already HIV-negative and take it every day. People starting PrEP should also use condoms and get tested for HIV and other STIs regularly.
Truvada may affect your kidneys, so your doctor will likely check your kidney function before and during treatment. It can also reduce bone density over time, especially in children and teens. Your doctor may recommend supplements or bone scans if needed.
Some rare but serious side effects include lactic acidosis (a buildup of acid in the blood), liver problems, and bone softening. Let your doctor know if you experience muscle pain, trouble breathing, tiredness, or unusual stomach symptoms.
Truvada can interact with other medications, especially ones that affect your kidneys. Let your doctor know about everything you take, including over-the-counter drugs and supplements.
The most common side effects of Truvada include headache, nausea, tiredness, diarrhea, and dizziness. Some people may also experience rash, abnormal dreams, trouble sleeping, or mild stomach pain. When used for HIV prevention, decreased weight and stomach discomfort may also occur. These effects are usually manageable and often go away with continued use.
Truvada can also cause more serious side effects, including kidney problems and changes in bone health, such as bone pain or thinning. Rare but serious risks include lactic acidosis and liver problems, which may cause symptoms like severe fatigue, nausea, yellowing of the skin or eyes, or dark urine. Some people may develop new symptoms as their immune system recovers while treating HIV. Let your healthcare provider know right away if you notice anything unusual while taking Truvada.
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