Trulance (Plecanatide)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Trulance (plecanatide) is used for the treatment of chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C) in adults.

Fact Table




US FDA, US DailyMed


Not orally bioavailable in humans

Legal status


Chemical Name


Elimination half-life

Cannot be calculated

Dosage (Strength)



Consult Doctor



Protein binding

Little to no binding

PubChem CID






ATC code






Routes of administration

By mouth


Trulance tablets are available in a 3-mg strength and should be swallowed whole. Talk to your doctor or your pharmacist if you are unable to swallow the tablets whole or if you have a feeding tube.

Recommended dosing in adults:

CIC: 3 mg by mouth once a day

IBS-C: 3 mg by mouth once a day

Trulance can be taken with or without food.


Plecanatide is the active ingredient in Trulance. 


Children who are younger than 6 years old should not take Trulance due to the risk of severe dehydration.

You should not take Trulance if you have or suspect that you have a mechanical gastrointestinal obstruction.



See full prescribing information for complete boxed warning.

  • TRULANCE is contraindicated in patients less than 6 years of age; in young juvenile mice, plecanatide caused death due to dehydration. 
  • Avoid use of TRULANCE in patients 6 years to less than 18 years of age. 
  • The safety and effectiveness of TRULANCE have not been established in patients less than 18 years of age. 
  • Before you start treatment with Trulance, you should discuss the following with your doctor:
    • Your medical history and medical conditions
    • Your allergies
    • All the medications you take, including prescription, nonprescription, vitamins, and herbal supplements
    • If you are pregnant or plan to become pregnant
    • If you are nursing or plan to nurse your baby
  • Trulance may cause harm to patients less than 18 years old and should be avoided in these patients.

Side Effects

Diarrhea is the most common side effect of Trulance. You may notice diarrhea within the first month of taking Trulance. If your diarrhea becomes severe, stop taking Trulance and tell your doctor right away.

Trulance may cause other side effects. Tell your doctor right away if you experience side effects that are troublesome or persistent.


  1. Trulance Prescribing Information. Bridgewater, NJ: Salix Pharmaceuticals; 2021.
  2. Trulance (plecanatide). Important Safety Information. Accessed February 1, 2022.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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