Trintellix (Vortioxetine)

Also Known as Brintellix

Prescription medicineOnly Available By Prescription

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You'll have option to make 4 interest-free payments by credit card once your order is confirmed using

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You'll have option to make 4 interest-free payments by credit card once your order is confirmed using

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Brintellix® (vortioxetine) for the treatment of major depressive disorder in adults

Fact Table







Legal status


Chemical Name


Elimination half-life

66 hours

Dosage (Strength)

5mg, 10mg, 15mg, 20mg


Not recommended



Protein binding


PubChem CID






ATC code






Routes of administration

By mouth


Before you begin taking Trintellix, tell your doctor your medical history, especially of: personal or family history of bipolar/manic-depressive disorder, personal or family history of suicide attempts, seizures, low sodium in the blood, intestinal ulcers/bleeding (peptic ulcer disease) or bleeding problems, personal or family history of glaucoma.

Side Effects

  • Constipation
  • Nausea
  • Dry mouth
  • Dizziness

Frequently Asked Questions about Trintellix

What is Trintellix used for?

Trintellix is a prescription medication for treating major depressive disorder (MDD) in adults. It helps rebalance brain chemicals.

Why is Trintellix so expensive?

Trintellix's high cost reflects the extensive research and testing required to ensure its safety and effectiveness as a brand-name medication.

Does Trintellix cause weight gain?

While clinical trials didn't show significant weight changes, some users have reported weight gain after starting Trintellix.

Can you take more than 20 mg of Trintellix?

No, the safety and effectiveness of doses above 20 mg/day haven't been studied in controlled trials. The maximum dosage for treating depression is 20 mg/day.

How long does Trintellix take to work?

Most people notice some improvement after two weeks, but it may take four weeks or longer to experience the full benefits of Trintellix.

Is Trintellix a controlled substance?

No, Trintellix isn't classified as a controlled substance.

Can Trintellix help anxiety?

While not FDA-approved for anxiety, Trintellix has been used off-label for severe cases of generalized anxiety disorder (GAD).

What are the side effects of Trintellix?

Trintellix can cause a range of side effects, including nausea (the most common), as well as itching, weight gain, gastrointestinal issues, headaches, and more serious effects like serotonin syndrome or allergic reactions.

What exactly does Trintellix do?

Trintellix is believed to work as an antidepressant by increasing serotonin activity in the brain, primarily by blocking its reuptake.

What is the most common side effect of Trintellix?

Nausea is the most reported side effect of Trintellix use.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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